Banner B F, Tomas-De La Vega J E, Roseman D L, Coon J S
Ann Surg. 1985 Dec;202(6):740-4. doi: 10.1097/00000658-198512000-00014.
Conventional prognostic parameters for colon carcinoma are predominantly determined after resection and have limited predictive value. For an evaluation of the significance of flow cytometric (FCM) DNA analysis in colon carcinoma, 56 invasive colon carcinomas were prospectively studied to compare DNA ploidy with established prognostic parameters obtained from pathologic examination of resected specimens. Objective parameters, i.e., depth of invasion and node status, were strongly linked to DNA ploidy; diploid tumors tended to be Astler-Coller stage A or B and nondiploid tumors stage C or D. Diploid and nondiploid tumors did not differ according to subjective criteria such as histologic grade and microscopic invasion of vessels and nerves. These results suggest that FCM DNA analysis may be a valuable tool in managing patients with colon carcinoma, since analysis of biopsies could indicate the likelihood of tumor spread before surgery.
结肠癌的传统预后参数主要在切除术后确定，其预测价值有限。为了评估流式细胞术（FCM）DNA分析在结肠癌中的意义，我们前瞻性地研究了56例浸润性结肠癌，以比较DNA倍体与从切除标本的病理检查中获得的既定预后参数。客观参数，即浸润深度和淋巴结状态，与DNA倍体密切相关；二倍体肿瘤倾向于处于阿斯特勒-科勒分期A或B期，而非二倍体肿瘤处于C或D期。根据组织学分级以及血管和神经的微观浸润等主观标准，二倍体和非二倍体肿瘤并无差异。这些结果表明，FCM DNA分析可能是管理结肠癌患者的一种有价值的工具，因为活检分析可以在手术前提示肿瘤扩散的可能性。
