年轻结直肠癌患者DNA含量异常的预后意义
Prognostic significance of DNA content abnormalities in young patients with colorectal cancer.
作者信息
Heimann T M, Martinelli G, Szporn A, Kurtz R J, Quish A, Miller F, Oh S C, Fasy T
机构信息
Department of Surgery, Mount Sinai School of Medicine, City University of New York, New York 10029.
出版信息
Ann Surg. 1989 Dec;210(6):792-5.
Several studies have shown that the presence of DNA ploidy abnormalities, measured by flow cytometry, may correlate with a poor prognosis in a variety of cancers. The predictive value of these DNA abnormalities in young patients with colorectal cancer has not been well studied. Fifty patients aged 40 years and younger with colorectal adenocarcinoma were studied to determine the correlation of tumor DNA abnormalities with survival. DNA content was determined by flow cytometric analysis and each tumor was categorized as diploid or nondiploid. Of the parameters studied, Dukes' classification and tumor DNA ploidy were found to be significant prognostic indicators. Determination of DNA content seems to provide additional useful prognostic information in young patients with colorectal cancer.
多项研究表明，通过流式细胞术检测到的DNA倍体异常的存在可能与多种癌症的预后不良相关。这些DNA异常在年轻结直肠癌患者中的预测价值尚未得到充分研究。对50例40岁及以下的结直肠腺癌患者进行研究，以确定肿瘤DNA异常与生存的相关性。通过流式细胞术分析确定DNA含量，每个肿瘤被分类为二倍体或非二倍体。在所研究的参数中，发现杜克分期和肿瘤DNA倍体是重要的预后指标。DNA含量的测定似乎为年轻结直肠癌患者提供了额外有用的预后信息。
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