帕金森病患者睡眠质量差：一项荟萃分析与系统评价
Poor sleep quality among patients with Parkinson's disease: a meta-analysis and systematic review.
作者信息
Si Tong Leong, Wang Yue-Ying, Li Jia-Xin, Bai Wei, Sun He-Li, Rao Shu-Ying, Zhu Han-Yu, Ungvari Gabor S, Su Zhaohui, Cheung Teris, Ng Chee H, Xiang Yu-Tao, Wang Gang
机构信息
Macao Observatory for Social Development, University of Saint Joseph, Macao, Macao SAR, China.
Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao, Macao SAR, China.
出版信息
Front Psychiatry. 2025 Jul 16;16:1606743. doi: 10.3389/fpsyt.2025.1606743. eCollection 2025.
OBJECTIVE
Poor sleep quality is common among patients with Parkinson's disease (PD), although the reported prevalence rates vary between studies. This meta-analysis examined the overall prevalence of poor sleep quality in patients with PD and identified potential factors contributing to the differences in prevalence across studies.
METHODS
Both PRISMA and MOOSE guidelines were applied in this meta-analysis. A systematic search was conducted in PubMed, EMBASE, PsycINFO, Web of Science, CNKI and Wangfang from their inception to November 4, 2023. Studies were selected based on predefined PICOS criteria (i.e., PD patients, prevalence of poor sleep quality, cross-sectional/cohort designs). Study quality/risk of bias was assessed using a standardized 8-item tool. Pooled prevalence was calculated sources of heterogeneity (e.g., age, sex, depression, anxiety, cognition scores, disease severity, and medication dose) were explored via subgroup and meta-regression analyses. A random-effects model was utilized to calculate the overall prevalence and corresponding 95% confidence intervals (CIs).
RESULTS
In total, 63 studies involving 9,382 PD patients were included. The overall prevalence of poor sleep quality was 58.07% (95% CI: 54.26-61.88%). Higher rates were related to various factors including studies from Europe & Central Asia, Upper middle income countries, mixed patient sources, lower diagnostic cutoffs, and use of Movement Disorder Society PD criteria. Meta-regression analysis showed that late onset PD was associated with poorer sleep quality in patients with PD.
CONCLUSION
Poor sleep quality is common in PD patients. Regular monitoring of sleep quality and promotion of sleep hygiene should be prioritized in the management of patients with PD. Additionally, further research on sleep and PD is warranted in low- and middle-income countries to ensure the applicability of findings across diverse populations.
SYSTEMATIC REVIEW REGISTRATION
https://inplasy.com/inplasy-2023-10-0022/, identifier INPLASY2023100022.
目的
帕金森病（PD）患者睡眠质量差很常见，尽管不同研究报告的患病率有所不同。本荟萃分析研究了PD患者睡眠质量差的总体患病率，并确定了导致各研究患病率差异的潜在因素。
方法
本荟萃分析采用了PRISMA和MOOSE指南。从数据库建立至2023年11月4日，在PubMed、EMBASE、PsycINFO、Web of Science、中国知网和万方数据进行了系统检索。根据预先定义的PICOS标准（即PD患者、睡眠质量差的患病率、横断面/队列设计）选择研究。使用标准化的8项工具评估研究质量/偏倚风险。计算合并患病率，并通过亚组分析和Meta回归分析探索异质性来源（如年龄、性别、抑郁、焦虑、认知评分、疾病严重程度和药物剂量）。采用随机效应模型计算总体患病率及相应的95%置信区间（CI）。
结果
共纳入63项研究，涉及9382例PD患者。睡眠质量差的总体患病率为58.07%（95%CI：54.26 - 61.88%）。较高的患病率与多种因素有关，包括来自欧洲和中亚的研究、中高收入国家的研究、混合患者来源、较低的诊断阈值以及使用运动障碍协会的PD标准。Meta回归分析表明，晚发型PD与PD患者较差的睡眠质量相关。
结论
睡眠质量差在PD患者中很常见。在PD患者的管理中，应优先定期监测睡眠质量并促进睡眠卫生。此外，低收入和中等收入国家有必要对睡眠与PD进行进一步研究，以确保研究结果适用于不同人群。
系统评价注册
https://inplasy.com/inplasy-2023-10-0022/，标识符INPLASY2023100022。
Zotero 插件