Yi Qu, Yu-Peng Chen, Jiang-Ting Li, Jing-Yi Li, Qi-Xiong Qin, Dan-Lei Wang, Jing-Wei Zhao, Zhi-Juan Mao, Yong-Jie Xiong, Zhe Min, Zheng Xue
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Aging Neurosci. 2022 Jun 10;14:887094. doi: 10.3389/fnagi.2022.887094. eCollection 2022.
Sleep disorders are the most common and disabling symptoms in patients with Parkinson's disease (PD). Understanding the associations between sleep characteristics and motor and non-motor symptoms (NMSs) in PD can provide evidence to guide therapeutic interventions and nursing strategies. We aimed to investigate the association between sleep characteristics and motor function and NMSs in PD using multiple approaches.
A total of 328 participants were included, and all participants underwent Pittsburgh Sleep Quality Index (PSQI) evaluation and clinical assessments of PD symptoms. We conducted Spearman's correlation to evaluate the associations between sleep and PD symptoms, nonlinear regression to assess the relationships between sleep habits and PD, and mediated analyses to test the effects of NMSs on global PSQI and PD severity, quality of life, and motor symptoms.
Poor sleep was associated with more severe PD symptoms. In addition, the reflection point for bedtime was around 21:52, associated with motor symptoms, and insufficient and excessive total time spent in bed and nocturnal sleep duration were correlated with higher NMS burdens. The optimal points were 8-9.2 and 6.2-6.9 h, respectively. It was also discovered that NMSs played the mediating roles in global sleep with the quality of life, PD stages, and motor symptoms to a varying range of 6.8-95.4%.
Sleep disorders have a significant effect on the burden of PD symptoms. The current findings provide new insights into the monitoring and management of sleep and PD and need to be further explored in the future studies.
睡眠障碍是帕金森病（PD）患者最常见且致残的症状。了解PD患者睡眠特征与运动及非运动症状（NMSs）之间的关联可为指导治疗干预和护理策略提供依据。我们旨在采用多种方法研究PD患者睡眠特征与运动功能及NMSs之间的关联。
共纳入328名参与者，所有参与者均接受匹兹堡睡眠质量指数（PSQI）评估及PD症状的临床评估。我们进行Spearman相关性分析以评估睡眠与PD症状之间的关联，进行非线性回归分析以评估睡眠习惯与PD之间的关系，并进行中介分析以检验NMSs对整体PSQI、PD严重程度、生活质量和运动症状的影响。
睡眠不佳与更严重的PD症状相关。此外，就寝时间的转折点约为21:52，与运动症状相关，卧床总时间和夜间睡眠时间不足及过长均与更高的NMS负担相关。最佳时间分别为8 - 9.2小时和6.2 - 6.9小时。还发现NMSs在整体睡眠与生活质量、PD分期及运动症状之间起到中介作用，中介效应范围在6.8% - 95.4%之间。
睡眠障碍对PD症状负担有显著影响。目前的研究结果为睡眠与PD的监测和管理提供了新的见解，有待在未来研究中进一步探索。
