Zhao Na, Fan Yameng
Office for Nosocomial Infection Control, Xi'an Central Hospital, Xi'an, China.
School of Public Health, Xi'an Medical University, Xi'an, China.
Front Public Health. 2025 Jul 16;13:1554687. doi: 10.3389/fpubh.2025.1554687. eCollection 2025.
The association between cardiovascular disease health (CVH) and frailty has not been conclusive. The American Heart Association (AHA) has proposed the Life's Essential 8 (LE8) score as an indicator of CVH. We sought to examine the association between LE8 and frailty among older people from the US general population.
We analyzed data from the 2015-2018 National Health and Nutrition Examination Survey and included older people aged ≥60 years. The LE8 score includes 8 metrics (4 health behaviors and 4 health factors). Frailty status was assessed using the FRAIL scale based on 5 criteria. Multivariate logistic regression analyses were used to assess associations.
A total of 2,511 older people (aged 60 years, with a weighted number of 49,532,259) were included. Among them, 1,294 (weighted percentage: 46.0%) were male and 1,217 (weighted percentage: 54.0%) were female. Older people with a higher LE8 score had a lower risk of frailty, the odds ratio (OR) for each standard deviation (SD) increase in the LE8 score was 0.59 (95% CI, 0.48-0.71, < 0.001). Similar results were observed in the associations of the health behaviors [OR 0.62 (95% CI, 0.50-0.78), < 0.001] and health factors [OR 0.76 (95% CI, 0.60-0.96), = 0.024] with frailty. After excluding older people with poor health status, the results remained significant, the OR for per SD score increase was 0.57 (95% CI, 0.46-0.69, < 0.001).
A higher LE8 score was associated with lower risk of frailty among older people in the US. Adherence to optimal CVH scores may be beneficial in helping prevent frailty.
心血管疾病健康（CVH）与衰弱之间的关联尚无定论。美国心脏协会（AHA）提出了生命基本8要素（LE8）评分作为CVH的一个指标。我们试图研究美国普通人群中老年人的LE8与衰弱之间的关联。
我们分析了2015 - 2018年国家健康与营养检查调查的数据，纳入了年龄≥60岁的老年人。LE8评分包括8个指标（4种健康行为和4种健康因素）。使用基于5项标准的衰弱量表评估衰弱状态。采用多变量逻辑回归分析来评估关联。
共纳入2511名老年人（年龄≥60岁，加权人数为49532259）。其中，1294名（加权百分比：46.0%）为男性，1217名（加权百分比：54.0%）为女性。LE8评分较高的老年人衰弱风险较低，LE8评分每增加一个标准差（SD），优势比（OR）为0.59（95%可信区间，0.48 - 0.71，P < 0.001）。在健康行为[OR 0.62（95%可信区间，0.50 - 0.78），P < 0.001]和健康因素[OR 0.76（95%可信区间，0.60 - 0.96），P = 0.024]与衰弱的关联中也观察到类似结果。排除健康状况较差的老年人后，结果仍然显著，每增加一个SD评分的OR为0.57（95%可信区间，0.46 - 0.69，P < 0.001）。
在美国老年人中，较高的LE8评分与较低的衰弱风险相关。坚持最佳的CVH评分可能有助于预防衰弱。
