Liang Kangni, Zhang Xiaoling
Zhejiang Chinese Medical University, Hangzhou, China.
Department of Neurology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Front Aging Neurosci. 2024 Apr 4;16:1386498. doi: 10.3389/fnagi.2024.1386498. eCollection 2024.
Life's Essential 8 (LE8) is prompted by the American Heart Association (AHA) to assess cardiovascular health. The association between LE8 and cognitive function in America is unknown. Our study was to investigate the association of LE8 with cognitive function in general adults.
A total of 2,301 participants were enrolled in the National Health and Nutrition Examination Surveys (NHANES). LE8 scores (range 0-100) were obtained from measurements based on American Heart Association definitions, divided into health behavior and health factor scores. Cognitive function was assessed by three tests including the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Animal fluency test (AFT), and Digit Symbol Substitution test (DSST). The multivariable linear regression analysis explored the associations between LE8 and cognitive function. Smooth curve fitting was explored using restricted cubic splines. The inflection point was determined by the two-piecewise linear regression.
In the multivariable linear regression model with full adjustment for confounding variables, AFT scores were 1.2 points higher in participants with LE8 scores >80 than in those with LE8 scores <50 (high LE8 score group: = 1.20, 95% CI 0.37, 2.03), and 3.32 points higher in DSST (high LE8 score group: = 3.32, 95% CI 1.24, 5.39). Although high LE8 scores show a Negative association with high CERAD, we found a significant association between higher LE8 scores and higher CERAD when LE8 scores were higher than 82.5 ( = 0.21 95%CI 0.04, 0.39, -value = 0.0179).
Our study highlighted a positive association between Life's Essential 8 and cognitive function in older adults.
美国心脏协会（AHA）提出了“生命关键8要素”（LE8）以评估心血管健康状况。在美国，LE8与认知功能之间的关联尚不清楚。我们的研究旨在调查一般成年人中LE8与认知功能之间的关联。
共有2301名参与者纳入了国家健康与营养检查调查（NHANES）。根据美国心脏协会的定义，通过测量得出LE8评分（范围为0 - 100），分为健康行为评分和健康因素评分。认知功能通过三项测试进行评估，包括阿尔茨海默病注册协会（CERAD）测试、动物流畅性测试（AFT）和数字符号替换测试（DSST）。多变量线性回归分析探讨了LE8与认知功能之间的关联。使用受限立方样条进行平滑曲线拟合。通过两段式线性回归确定拐点。
在对混杂变量进行完全调整的多变量线性回归模型中，LE8评分>80的参与者的AFT评分比LE8评分<50的参与者高1.2分（高LE8评分组：β = 1.20，95%CI 0.37，2.03），DSST评分高3.32分（高LE8评分组：β = 3.32，95%CI 1.24，5.39）。尽管高LE8评分与高CERAD评分呈负相关，但当LE8评分高于82.5时，我们发现较高的LE8评分与较高的CERAD评分之间存在显著关联（β = 0.21，95%CI 0.04，0.39，P值 = 0.0179）。
我们的研究强调了老年人的生命关键8要素与认知功能之间存在正相关。
