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评估宫颈癌治疗中获取和完成放射治疗的延误情况:撒哈拉以南非洲进一步获得资助国家肿瘤医疗服务提供者的多中心调查

Assessing delays in accessing and completing radiotherapy for cervical cancer treatment: A multicenter survey of oncology providers in go further-funded countries in Sub-Saharan Africa.

作者信息

Kernell Caroline G, Kassick Megan, George Jessica M, Anakwenze Chidinma P, Trimble Edward L, Grover Surbhi

机构信息

UT Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75390, United States of America.

University of Pennsylvania, Department of Radiation Oncology, Perelman Center for Advanced Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States of America.

出版信息

Gynecol Oncol Rep. 2025 Jul 18;60:101810. doi: 10.1016/j.gore.2025.101810. eCollection 2025 Aug.

Abstract

OBJECTIVE

Cervical cancer is a leading cause of cancer death in Sub-Saharan Africa. Go Further provides funds for prevention and screening in Sub-Saharan Africa, but access to treatment for invasive disease remains limited. This survey aims to assess delays in accessing curative-intent chemoradiotherapy for cervical cancer in countries receiving Go Further funding.

METHODS

Oncology providers in countries receiving Go Further funding (Botswana, Eswatini, Ethiopia, Kenya, Lesotho, Malawi, Mozambique, Namibia, Tanzania, Uganda, Zambia, Zimbabwe) and South Africa were invited to participate in a web-based survey beginning September 2023.

RESULTS

Fifteen oncology providers responded, with all countries except Malawi represented. Nearly half (46.3 %) reported wait time of ≥two months for chemoradiotherapy consultation. 93.3 %, 71.4 %, 53.7 % and 73.3 % had access to at least one CT, linear accelerator, cobalt, and brachytherapy machine, respectively. Majority (60 %) reported wait time of <one month to initiate chemoradiotherapy after staging. However, 28.6 % reported >95 % of patients complete external radiotherapy within 42 days, and 33 % reported >95 % of these patients receive brachytherapy. Only 26.7 % reported overall treatment time within 56 days for >95 % of patients. Lack of transportation, funding, and patient fear, were other treatment barriers reported.

CONCLUSION

These results highlight the need for additional chemoradiotherapy resources in Go Further-funded countries. In addition to expanding radiotherapy, supplemental avenues to improve access in Sub-Saharan Africa include addressing barriers that increase wait times along the care continuum and implementing social support. This survey serves as a call to Go Further, highlighting the urgent need for resource allocation for cervical cancer treatment.

摘要

目的

宫颈癌是撒哈拉以南非洲地区癌症死亡的主要原因。“进一步行动”项目为撒哈拉以南非洲地区的预防和筛查提供资金,但侵袭性疾病的治疗机会仍然有限。本调查旨在评估接受“进一步行动”项目资金的国家在获得宫颈癌根治性放化疗方面的延误情况。

方法

接受“进一步行动”项目资金的国家(博茨瓦纳、斯威士兰、埃塞俄比亚、肯尼亚、莱索托、马拉维、莫桑比克、纳米比亚、坦桑尼亚、乌干达、赞比亚、津巴布韦)以及南非的肿瘤学提供者被邀请参加始于2023年9月的一项基于网络的调查。

结果

15名肿瘤学提供者做出回应,除马拉维外所有国家均有代表。近一半(46.3%)报告放化疗咨询等待时间≥两个月。分别有93.3%、71.4%、53.7%和73.3%能够使用至少一台CT、直线加速器、钴源和近距离放疗设备。大多数(60%)报告分期后开始放化疗的等待时间<一个月。然而,28.6%报告>95%的患者在42天内完成外照射放疗,33%报告这些患者中有>95%接受近距离放疗。只有26.7%报告>95%的患者总体治疗时间在56天内。报告的其他治疗障碍包括缺乏交通、资金以及患者恐惧。

结论

这些结果凸显了在接受“进一步行动”项目资金的国家增加放化疗资源的必要性。除了扩大放疗资源外,改善撒哈拉以南非洲地区治疗可及性的补充途径包括消除增加整个护理过程等待时间的障碍以及提供社会支持。本次调查呼吁“进一步行动”项目,强调为宫颈癌治疗进行资源分配的迫切需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc9d/12309483/78b8cd6ad41c/gr1.jpg

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