Peng Yao, Xie Man-Ying, Gan Ling, Zhang Jia-Qi
Department of Ultrasound Imaging, Postgraduate Union Training Base of Xiangyang No. 1 People's Hospital, Xiangyang 441000, Hubei Province, China.
School of Medicine, Wuhan University of Science and Technology, Xiangyang 441100, Hubei Province, China.
World J Gastrointest Surg. 2025 Jul 27;17(7):107259. doi: 10.4240/wjgs.v17.i7.107259.
Postoperative depression is a prevalent yet often overlooked complication following radical surgery for gastric cancer that significantly affects patient recovery and quality of life. Emerging evidence suggests that the gut microbiota has a crucial role in the gut-brain axis, influencing mood regulation and psychological resilience. In the study by Lu , triple viable bacteria combined with mirtazapine demonstrated marked efficacy: The observation group showed a 32% reduction in Self-Rating Depression Scale depression scores, significantly outperforming the control group. Neuroendocrine improvements included a 89% increase in dopamine and a 43% reduction in cortisol. Gut microbiota modulation was evident with colony counts rising by 22%, while decreased by 28%. Quality of life scores improved by 39%, underscoring the therapy's holistic benefits. These findings validate the synergistic potential of microbiota-targeted probiotics and psychotropic drugs. Early screening, multidisciplinary care, and personalized strategies integrating psychological support, dietary optimization, and lifestyle modifications are essential to enhance recovery and redefine postoperative management in gastric cancer patients.
术后抑郁是胃癌根治术后一种常见但常被忽视的并发症，严重影响患者康复和生活质量。新出现的证据表明，肠道微生物群在肠-脑轴中起关键作用，影响情绪调节和心理恢复力。在卢的研究中，三联活菌联合米氮平显示出显著疗效：观察组的自评抑郁量表抑郁评分降低了32%，明显优于对照组。神经内分泌改善包括多巴胺增加89%和皮质醇降低43%。肠道微生物群调节明显，菌落计数增加22%，而减少28%。生活质量评分提高了39%，突出了该疗法的整体益处。这些发现证实了针对微生物群的益生菌和精神药物的协同潜力。早期筛查、多学科护理以及整合心理支持、饮食优化和生活方式改变的个性化策略对于提高胃癌患者的康复水平和重新定义术后管理至关重要。
