Zhang Yike, Zhang Tingting, Zhao Manli, Li Peichun, Liu Tao, Xie Jiangbo
Clinical Integration of Traditional Chinese and Western Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Neurology, Weifang Traditional Chinese Hospital, Weifang, China.
Front Pharmacol. 2025 Jul 16;16:1618623. doi: 10.3389/fphar.2025.1618623. eCollection 2025.
Neurological disorders (e.g., Alzheimer's disease, Parkinson's disease, and stroke) have complex pathogenesis and affect a substantial proportion of the population; yet, available treatments have poor or limited efficacy, and the patients have a poor prognosis, with high morbidity and mortality. Dihydromyricetin (DHM), a flavonoid compound extracted from plants, has received widespread attention in recent years because of its diverse pharmacological effects. and studies have revealed its substantial antioxidant, anti-inflammatory, and neuroprotective properties, making it a promising candidate for the treatment of central nervous system disorders through multiple mechanisms and pleiotropic effects. Therefore, there is an urgent need to develop novel therapeutic strategies. DHM is an attractive candidate for the management of neurological disorders, but there is a lack of a systematic summary of the knowledge status and gaps. Therefore, to address this challenge, we systematically reviewed the pharmacological mechanisms of DHM in central nervous system disorders and its potential applications in related conditions. We analyzed the therapeutic potential and current challenges of DHM to provide a reference for its development and application as a novel therapeutic agent. The review suggests that DHM possesses significant potential for the management of neurological disorders.
神经疾病（如阿尔茨海默病、帕金森病和中风）具有复杂的发病机制，影响着相当一部分人群；然而，现有的治疗方法疗效不佳或有限，患者预后较差，发病率和死亡率较高。二氢杨梅素（DHM）是一种从植物中提取的黄酮类化合物，近年来因其多样的药理作用而受到广泛关注。多项研究揭示了其强大的抗氧化、抗炎和神经保护特性，使其成为通过多种机制和多效性作用治疗中枢神经系统疾病的有前景的候选药物。因此，迫切需要开发新的治疗策略。DHM是治疗神经疾病的一个有吸引力的候选药物，但缺乏对其知识现状和差距的系统总结。因此，为应对这一挑战，我们系统地综述了DHM在中枢神经系统疾病中的药理机制及其在相关病症中的潜在应用。我们分析了DHM的治疗潜力和当前面临的挑战，为其作为新型治疗药物的开发和应用提供参考。该综述表明，DHM在治疗神经疾病方面具有巨大潜力。
