Zu Jian, Cheng Lu, Lu Jing-Jing, Xu Hui, Zhang Rong, Ye Xue-Rui, Qiao Qian, Zhang Li-Hong, Zhang Hao-Ling, Zhang Jing-Jing
Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China.
Department of Cardiovascular Medicine, Fuwai Yunnan Hospital, Chinese Academy Medical Sciences, Kunming 650000, Yunnan Province, China.
World J Cardiol. 2025 Jul 26;17(7):109787. doi: 10.4330/wjc.v17.i7.109787.
This review comprehensively examines acute myocardial infarction with ventricular septal rupture (VSR), a rare yet lethal complication. We analyze its epidemiological, pathophysiological, clinical, and therapeutic aspects, emphasizing innovative strategies like bioabsorbable occluders and tissue engineering to reduce complications and improve prognosis. The integration of artificial intelligence and big data analytics for treatment decision-making and personalized surgical timing models is highlighted as transformative. Our analysis underscores the need for early diagnosis and tailored interventions, proposing future research directions in molecular mechanisms, multidisciplinary collaboration, and technology integration. These innovations promise to enhance VSR management and extend to other cardiovascular diseases, heralding a new era of precision and regenerative cardiovascular medicine.
本综述全面研究了急性心肌梗死合并室间隔破裂（VSR）这一罕见但致命的并发症。我们分析了其流行病学、病理生理学、临床和治疗方面，重点强调了生物可吸收封堵器和组织工程等创新策略，以减少并发症并改善预后。人工智能和大数据分析在治疗决策及个性化手术时机模型中的整合被视为具有变革性。我们的分析强调了早期诊断和量身定制干预措施的必要性，并提出了分子机制、多学科协作及技术整合等未来研究方向。这些创新有望改善VSR的管理，并扩展至其他心血管疾病，开创精准和再生心血管医学的新时代。
