Yuan Qiongzhen, Yang Zhouquan, Fan Wei, Chen Xiaofan, Zou Huan, Yuan Rongdi
Department of Ophthalmology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Front Endocrinol (Lausanne). 2025 Jul 16;16:1592618. doi: 10.3389/fendo.2025.1592618. eCollection 2025.
To investigate the influence of renal function on the surgical outcomes of vitrectomy in patients with proliferative diabetic retinopathy (PDR).
A secondary analysis was conducted on data from a retrospective cohort study.
A total of 128 eyes with PDR that underwent pars plana vitrectomy (PPV) and were followed up for at least 2 years were enrolled, including 65 eyes in the impaired renal function (IRF) group and 63 eyes in the normal renal function (NRF) group. No significant between-group differences were observed in the proportion of cataract surgery (p = 0.722), intraoperative retinal photocoagulation (p = 0.476), gas tamponade (p = 0.932), silicone oil tamponade (p = 0.254), retinal dialysis and/or iatrogenic retinal breaks (p = 0.447), and 23- or 25-gauge (G) microincision vitrectomy surgery (MIVS) (p = 0.160). Similarly, intergroup comparisons showed no significant differences in the proportion of reoperation (p = 0.883), postoperative vitreous hemorrhage (VH) and/or retinal detachment (RD) (p = 0.919), postoperative neovascular glaucoma (NVG) (p = 0.600), and postoperative diabetic macular edema (DME) (p = 0.794). Notably, the IRF group had worse baseline best corrected visual acuity (BCVA) (p = 0.039) and showed greater BCVA improvement at 3 months (p = 0.008), 6 months (p = 0.047), 1 year (p = 0.007), 2 years (p = 0.003), 3 years (p = 0.009), and 4 years (p = 0.024) after surgery. However, there was no significant difference in postoperative BCVA between the two groups at each follow-up time (all p > 0.05).
Renal insufficiency does not adversely affect the surgical outcomes of PPV in patients with PDR.
探讨肾功能对增殖性糖尿病视网膜病变（PDR）患者玻璃体切除术手术效果的影响。
对一项回顾性队列研究的数据进行二次分析。
共纳入128只接受了玻璃体切除术（PPV）且随访至少2年的PDR患眼，其中肾功能受损（IRF）组65只眼，肾功能正常（NRF）组63只眼。白内障手术比例（p = 0.722）、术中视网膜光凝（p = 0.476）、气体填充（p = 0.932）、硅油填充（p = 0.254）、视网膜脱离和/或医源性视网膜裂孔（p = 0.447）以及23G或25G微小切口玻璃体切除术（MIVS）（p = 0.160）在两组间均无显著差异。同样，组间比较显示再次手术比例（p = 0.883）、术后玻璃体出血（VH）和/或视网膜脱离（RD）（p = 0.919）、术后新生血管性青光眼（NVG）（p = 0.600）以及术后糖尿病性黄斑水肿（DME）（p = 0.794）也无显著差异。值得注意的是，IRF组的基线最佳矫正视力（BCVA）较差（p = 且在术后3个月（p = 0.008）、6个月（p = 0.047）、1年（p = 0.007）、2年（p = 0.003）、3年（p = 0.009）和4年（p = 0.024）时BCVA改善更大。然而，两组在各随访时间的术后BCVA均无显著差异（所有p > 0.05）。
肾功能不全不会对PDR患者PPV的手术效果产生不利影响。 039），
