长期使用质子泵抑制剂与胃癌的感知风险：弥合差距。

Perceived risk of gastric cancer associated with long-term use of proton pump inhibitors: Bridging the gap.

作者信息

Sawaied Ibrahim O, Samson Abraham O, Golan Efrat

机构信息

Azrieli Faculty of Medicine, Bar Ilan University, Safed 21700000, Israel.

Department of Pediatric Medicine, Haemek Hospital, Afula 2170000, Israel.

出版信息

World J Clin Oncol. 2025 Jul 24;16(7):107091. doi: 10.5306/wjco.v16.i7.107091.

DOI:10.5306/wjco.v16.i7.107091

PMID:40741202

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12305034/

Abstract

BACKGROUND

Long-term use of proton pump inhibitors (PPIs) has been associated with potential adverse effects, including an increased risk of gastric cancer. Despite widespread use awareness of these risks among physicians varies considerably. Understanding physicians' perceptions and prescribing behaviors is critical to improving patient safety and promoting evidence-based practices. This study aimed to assess the level of awareness and risk perception among gastroenterologists and non-gastroenterologists regarding prolonged PPI use and its association with gastric malignancy.

AIM

To assess physicians' awareness of gastric cancer risk associated with long-term PPI use and compare perceptions between specialties.

METHODS

A cross-sectional observational study was conducted among 33 physicians (15 gastroenterologists and 18 non-gastroenterologists) in Israel. Participants completed a structured questionnaire evaluating knowledge, attitudes, and prescribing behaviors related to PPI use. Data were analyzed using descriptive statistics and nonparametric tests to assess differences between groups and correlation patterns. Ethical approval and informed consent were obtained.

RESULTS

Gastroenterologists demonstrated significantly higher awareness of the potential gastric cancer risks linked to prolonged PPI use (mean awareness score: 6.9 ± 1.2) compared with non-gastroenterologists (4.1 ± 1.3, < 0.01). Despite their awareness 80% of gastroenterologists reported frequent long-term prescribing. Nonparametric correlation analysis revealed associations between specialty, knowledge level, and prescribing habits. Several misconceptions about cancer risk mechanisms were identified across specialties.

CONCLUSION

Physician awareness regarding gastric cancer risk of long-term PPI use remains inconsistent, especially among non-specialists, emphasizing the need for targeted educational programs and clearer prescribing guidelines.

摘要

背景

长期使用质子泵抑制剂（PPI）与潜在的不良反应相关，包括胃癌风险增加。尽管PPI广泛使用，但医生对这些风险的认知差异很大。了解医生的认知和处方行为对于提高患者安全性和促进循证实践至关重要。本研究旨在评估胃肠病学家和非胃肠病学家对长期使用PPI及其与胃恶性肿瘤关联的认知水平和风险感知。

目的

评估医生对长期使用PPI相关胃癌风险的认知，并比较不同专业之间的认知差异。

方法

在以色列对33名医生（15名胃肠病学家和18名非胃肠病学家）进行了一项横断面观察性研究。参与者完成了一份结构化问卷，评估与PPI使用相关的知识、态度和处方行为。使用描述性统计和非参数检验分析数据，以评估组间差异和相关模式。获得了伦理批准和知情同意。

结果

与非胃肠病学家（4.1±1.3，<0.01）相比，胃肠病学家对长期使用PPI潜在的胃癌风险表现出明显更高的认知（平均认知得分：6.9±1.2）。尽管有认知，但80%的胃肠病学家报告经常长期开PPI处方。非参数相关分析揭示了专业、知识水平和处方习惯之间的关联。在各个专业中都发现了一些关于癌症风险机制的误解。