Hussein Hisham Mohamed, Gabr Ahmed Maher Mohamed, Fadulelmulla Ibtisam Abdallah, Aldemery Ahmed Abdelmageed, Ragab Mohamed Marzouk Mohamed, Mohamed Amany Raafat, Dewir Ibrahim Metwally, Ibrahim Ahmed Abdelmoniem
Department of Physical Therapy, College of Aplied Medical Sciences, University of Ha'il, Ha'il, Saudi Arabia.
Department of Basic Sciences for Physical Therapy, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
Arch Med Sci. 2024 May 13;21(3):889-896. doi: 10.5114/aoms/186874. eCollection 2025.
This review analysed the efficiency of low-level laser therapy in treating breast cancer-related lymphedema (BCRL) in women.
Databases such as Scopus, PEDro, PubMed, Cochrane, and Web of Science were searched for RCTs using low-level laser therapy (LLLT) or photo-bio modulation therapy (PBMT) on BCRL published between 2010 and August 2023. Primary outcomes were arm circumference, volume, and hand grip strength, while secondary outcomes were pain, shoulder mobility, and quality of life.
Eleven RCTs with a total of 379 patients were analysed, and 8 studies were included for meta-analysis. We found no significant difference between laser-treated and control groups in any of the trials in terms of arm circumference, arm volume, grip strength, and quality of life post-intervention, and a significant difference between the groups in terms of pain intensity and shoulder mobility.
This review revealed that low-level laser therapy (photobiostimulation) was successful in reducing arm circumference, volume, and pain, as well as enhancing grip strength, life quality, and mobility. However, the meta-analysis did not show any improvement except in pain and shoulder mobility. Further trials are required to assess the long- and short-term efficacy of LLLT in managing lymphoedema secondary to breast cancer.
本综述分析了低强度激光疗法治疗女性乳腺癌相关淋巴水肿（BCRL）的疗效。
检索了Scopus、PEDro、PubMed、Cochrane和Web of Science等数据库，以查找2010年至2023年8月期间发表的关于使用低强度激光疗法（LLLT）或光生物调节疗法（PBMT）治疗BCRL的随机对照试验（RCT）。主要结局指标为上臂周长、体积和握力，次要结局指标为疼痛、肩部活动度和生活质量。
分析了11项随机对照试验，共379例患者，纳入8项研究进行荟萃分析。我们发现，在干预后的上臂周长、上臂体积、握力和生活质量方面，各试验中激光治疗组与对照组之间均无显著差异，而在疼痛强度和肩部活动度方面，两组之间存在显著差异。
本综述表明，低强度激光疗法（光生物刺激）在减小上臂周长、体积和疼痛，以及增强握力、生活质量和活动度方面取得了成功。然而，荟萃分析显示，除了疼痛和肩部活动度外，没有任何改善。需要进一步的试验来评估低强度激光疗法治疗乳腺癌继发淋巴水肿的长期和短期疗效。
