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5' 三磷酸胞苷转移核糖核酸 - 谷氨酸 - TTC靶向瞬时受体电位香草酸亚型3（TRPV3）并激活磷脂酰肌醇-3-激酶/蛋白激酶B（PI3K/AKT）信号通路以调节皮肤光老化。

5'tiRNA-Glu-TTC targets TRPV3 and activates the PI3K/AKT signaling pathway to modulate skin photoaging.

作者信息

Xu Zhuohong, Liu Lihao, Dai Xiaoxi, Zhou Xuyue, Chen Lihao, Chen Hongying, Luan Chao, Huang Dan, Zhang Jiaan, Hu Yu, Chen Kun, Gu Heng

机构信息

Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.

出版信息

Noncoding RNA Res. 2025 Jul 14;15:29-43. doi: 10.1016/j.ncrna.2025.07.004. eCollection 2025 Dec.

DOI:10.1016/j.ncrna.2025.07.004
PMID:40741358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12310068/
Abstract

tRNA-derived small RNAs (tsRNAs), a class of non-coding RNAs (ncRNAs), have garnered increasing research interest for their potential roles in various biological processes. Among these, 5'tiRNA-Glu-TTC has been implicated in aging, but its role in skin photoaging remains elusive. This study aimed to elucidate the impact of 5'tiRNA-Glu-TTC on skin photoaging. RT-qPCR analysis revealed that 5'tiRNA-Glu-TTC expression increased in human dermal fibroblasts (HDFs), human skin tissues, and mouse skin tissues following UVB irradiation. In HDFs, transfection of a 5'tiRNA-Glu-TTC mimic induced photoaging phenotypes, while its inhibitor alleviated UVB-induced photoaging. This study found that 5'tiRNA-Glu-TTC participates in photoaging through binding to TRPV3. Overexpression of TRPV3 rescued the photoaging effects induced by the 5'tiRNA-Glu-TTC mimic. Furthermore, 5'tiRNA-Glu-TTC influences photoaging also by activating the PI3K/AKT signaling pathway, an effect that was reversed by TRPV3 overexpression. In vivo studies in nude mice showed that intradermal injection of 5'tiRNA-Glu-TTC adeno-associated virus alleviated UVB-induced skin aging phenotypes, including epidermal thickening, dermal collagen reduction, and increased transepidermal water loss (TEWL). Collectively, our findings demonstrate that 5'tiRNA-Glu-TTC mediates photoaging by targeting TRPV3 and activating the PI3K/AKT pathway.

摘要

转运RNA衍生的小RNA（tsRNAs）是一类非编码RNA（ncRNAs），因其在各种生物过程中的潜在作用而受到越来越多的研究关注。其中，5'tiRNA-Glu-TTC与衰老有关，但其在皮肤光老化中的作用仍不清楚。本研究旨在阐明5'tiRNA-Glu-TTC对皮肤光老化的影响。RT-qPCR分析显示，紫外线B（UVB）照射后人真皮成纤维细胞（HDFs）、人皮肤组织和小鼠皮肤组织中5'tiRNA-Glu-TTC表达增加。在HDFs中，转染5'tiRNA-Glu-TTC模拟物可诱导光老化表型，而其抑制剂可减轻UVB诱导的光老化。本研究发现，5'tiRNA-Glu-TTC通过与瞬时受体电位香草酸亚型3（TRPV3）结合参与光老化。TRPV3的过表达挽救了5'tiRNA-Glu-TTC模拟物诱导的光老化效应。此外，5'tiRNA-Glu-TTC还通过激活磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/AKT）信号通路影响光老化，TRPV3过表达可逆转这一效应。裸鼠体内研究表明，皮内注射5'tiRNA-Glu-TTC腺相关病毒可减轻UVB诱导下的皮肤老化表型，包括表皮增厚、真皮胶原蛋白减少和经表皮水分流失（TEWL）增加。总的来说，我们的研究结果表明，5'tiRNA-Glu-TTC通过靶向TRPV3和激活PI3K/AKT通路介导光老化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/4b15aeb12963/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/712371b22208/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/ae7fd5792484/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/0f36eaf70375/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/7405c7311714/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/e02b10a53dab/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/1683f3a2bdee/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/628eccdcc55e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/4b15aeb12963/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/712371b22208/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/ae7fd5792484/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/0f36eaf70375/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/7405c7311714/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/e02b10a53dab/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/1683f3a2bdee/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/628eccdcc55e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1676/12310068/4b15aeb12963/gr7.jpg

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本文引用的文献

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2
Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition.果酸通过抑制PI3K/Akt和NF-κB信号通路抑制紫外线诱导的皮肤衰老。
Discov Med. 2025 Jan;37(192):193-201. doi: 10.24976/Discov.Med.202537192.16.
3
Cosmetic retinoid use in photoaged skin: A review of the compounds, their use and mechanisms of action.
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Int J Cosmet Sci. 2025 Feb;47(1):45-57. doi: 10.1111/ics.13013. Epub 2024 Aug 11.
4
Injective hydrogel loaded with liposomes-encapsulated MY-1 promotes wound healing and increases tensile strength by accelerating fibroblast migration via the PI3K/AKT-Rac1 signaling pathway.载有脂质体包裹的 MY-1 的注射水凝胶通过 PI3K/AKT-Rac1 信号通路加速成纤维细胞迁移，从而促进伤口愈合并增加拉伸强度。
J Nanobiotechnology. 2024 Jul 5;22(1):396. doi: 10.1186/s12951-024-02666-3.
5
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Cell Metab. 2024 May 7;36(5):1059-1075.e9. doi: 10.1016/j.cmet.2024.02.011. Epub 2024 Mar 7.
6
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