J Drugs Dermatol. 2023 Sep 1;22(9):867-873. doi: 10.36849/JDD.7753.
Photoaging due to cumulative lifetime ultraviolet light exposure is the greatest contributing factor to facial aging. With the continued growth of the population of individuals aged ≥65 years and over, demand for safe and effective photoaging treatments will likely increase.
This qualitative review provides an overview of efficacy and safety of over-the-counter (OTC) and prescription topical treatments for photoaging, including recent data from an investigator-initiated trial of the topical retinoid tazarotene.
OTC and cosmeceutical products comprise the majority of treatment options for photoaging, although clinical data in support of their efficacy are generally lacking. Topical retinoids have been shown to increase collagen and elastic fibers and normalize melanocytes and keratinocytes, yielding improvements in wrinkling, texture, elasticity, and skin tone. Prescription topical retinoids (adapalene, tazarotene, tretinoin) are the most studied and efficacious treatments for photoaging, though their use is typically associated with adverse effects such as erythema, peeling, dryness, and burning/stinging in a concentration-dependent manner. In a 12-week, open-label study, lower-dose tazarotene 0.045% lotion led to significantly reduced signs and severity of photoaging vs baseline.
Prescription topical retinoids are the most potent treatment option for photoaging, though their use may be limited by irritation concerns. Tazarotene 0.045% polymeric emulsion lotion has recently demonstrated significant photoaging improvements with 12 weeks of once-daily treatment, with a favorable safety and tolerability profile.
Sadick N, Pannu S, Abidi Z, et al. Topical treatments for photoaged skin. J Drugs Dermatol. 2023;22(9):867-873. doi:10.36849/JDD.7753.
由于一生中累积的紫外线照射，光老化是导致面部衰老的最大因素。随着年龄在 65 岁及以上的人群持续增长，对安全有效的光老化治疗的需求可能会增加。
本定性综述概述了非处方（OTC）和处方局部治疗光老化的疗效和安全性，包括来自一项局部维 A 酸他扎罗汀的研究者发起试验的最新数据。
OTC 和化妆品产品构成了光老化治疗的大部分选择，尽管缺乏支持其疗效的临床数据。局部维 A 酸已被证明可以增加胶原蛋白和弹性纤维，并使黑素细胞和角质形成细胞正常化，从而改善皱纹、质地、弹性和肤色。处方局部维 A 酸（阿达帕林、他扎罗汀、维 A 酸）是研究最多且最有效的光老化治疗药物，但它们的使用通常与不良反应相关，如红斑、脱皮、干燥和以浓度依赖性方式的灼热/刺痛。在一项为期 12 周的开放性研究中，低剂量他扎罗汀 0.045%洗剂可显著减少光老化的体征和严重程度与基线相比。
处方局部维 A 酸是光老化的最有效治疗选择，但由于刺激问题，其使用可能受到限制。他扎罗汀 0.045%聚合物乳液洗剂最近在每天一次治疗 12 周后显示出对光老化的显著改善，具有良好的安全性和耐受性。
Sadick N, Pannu S, Abidi Z, et al. Topical treatments for photoaged skin. J Drugs Dermatol. 2023;22(9):867-873. doi:10.36849/JDD.7753.
