Treatment of juvenile laryngeal papilloma with a combination of laser surgery and interferon.

The therapeutic results obtained from the treatment of juvenile laryngeal papillomas with combined laser surgery and alpha-type IFN treatment are reported. Three cases of papilloma occurring under four years of age were found to be of the fulminant type with a strong tendency for recurrence. The results were complete remission of papilloma in two cases and a residual trace in one case. Thus, at present, control of the disease has been successful. A combination of several modes of treatment may be necessary for a more lasting therapeutic effect. Currently, no single method has been used to treat the disease. Laser surgery and IFN are both powerful therapies for this tenacious disease.