Do Minh Duc, Tran Tai Ngoc, Le Linh Hoang Gia, Mai Thao Phuong
Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Department of Neurology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Neurogenetics. 2025 Jul 31;26(1):56. doi: 10.1007/s10048-025-00840-9.
Parkinson's disease (PD) is a complex disorder with contributions by environmental and genetic factors. LRRK2 R1628P is a major genetic risk factor for developing PD in Asian populations. However, the effect of this variant in Kinh Vietnamese remains unclear. This study collected DNA samples of 832 subjects comprising 190 PD patients and 642 control cases, and the LRRK2 R1628P variant was genotyped using an allele-specific oligonucleotide PCR method. The prevalence of the GC genotype of LRRK2 R1628P was significantly higher in the PD group than in the control group, and the LRRK2 R1628P variant showed a significant association with PD with OR = 2.91 (95% CI = 1.50-5.62). LRRK2 R1628P was also found to be associated with PD in subpopulations for males, early-onset, and late-onset. These results emphasize the important genetic contribution of LRRK2 R1628P in the risk of developing PD in the Kinh Vietnamese population.
帕金森病（PD）是一种由环境和遗传因素共同作用导致的复杂疾病。LRRK2基因R1628P位点突变是亚洲人群患帕金森病的主要遗传风险因素。然而，该变异在京族越南人中的作用尚不清楚。本研究收集了832名受试者的DNA样本，其中包括190例帕金森病患者和642例对照，采用等位基因特异性寡核苷酸PCR方法对LRRK2基因R1628P位点进行基因分型。帕金森病组LRRK2基因R1628P位点GC基因型的患病率显著高于对照组，且LRRK2基因R1628P位点变异与帕金森病显著相关，比值比（OR）=2.91（95%置信区间CI=1.50 - 5.62）。在男性、早发型和晚发型亚组中也发现LRRK2基因R1628P位点与帕金森病相关。这些结果强调了LRRK2基因R1628P位点在京族越南人患帕金森病风险中的重要遗传作用。
