Tran Tuan Thanh, Mai Thao Phuong, Tran Ha Chau Bich, Le Linh Hoang Gia, Vu Hoang Anh, Tran Trang Kim, Hoang Sy Van, Chau Hoa Ngoc, Do Minh Duc
Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Department of Physiology-Pathophysiology-Immunology, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Front Cardiovasc Med. 2021 Feb 19;8:608948. doi: 10.3389/fcvm.2021.608948. eCollection 2021.
Increasing left ventricular mass in hypertensive patients is an independent prognostic marker for adverse cardiovascular outcomes. Genetic factors have been shown to critically affect left ventricular mass. M235T is one of the genetic polymorphisms that may influence left ventricular mass due to its pivotal role in the regulation of plasma angiotensinogen level as well as hypertension pathophysiology in Asian populations. Currently, how M235T affects left ventricular mass is not well-described in Vietnamese hypertensive patients. This study aimed to investigate the association between M235T and left ventricular mass in Vietnamese patients diagnosed with essential hypertension. M235T genotyping and 2D echocardiography were performed on 187 Vietnamese subjects with essential hypertension. All the ultrasound parameters were obtained to calculate the left ventricular mass index according to the American Society of Echocardiography and the European Association of Cardiovascular Imaging 2015 guidelines. Other clinical characteristics were also recorded, including age, gender, duration of hypertension, hypertensive treatment, lifestyle, renal function, fasting plasma glucose, and lipid profile. MT and TT genotypes were determined in 30 and 157 subjects, respectively. M235T genotype, duration of hypertension, body mass index, and ejection fraction statistically affected the left ventricular mass index, which was significantly greater in TT compared to MT carriers after adjusting for confounding factors. The TT genotype of M23T was associated with greater left ventricular mass in Vietnamese patients diagnosed with essential hypertension.
高血压患者左心室质量增加是不良心血管结局的独立预后标志物。遗传因素已被证明对左心室质量有至关重要的影响。M235T是一种基因多态性，由于其在调节血浆血管紧张素原水平以及亚洲人群高血压病理生理学中的关键作用，可能影响左心室质量。目前，在越南高血压患者中，M235T如何影响左心室质量尚未得到充分描述。本研究旨在调查越南原发性高血压患者中M235T与左心室质量之间的关联。对187名越南原发性高血压患者进行了M235T基因分型和二维超声心动图检查。根据美国超声心动图学会和欧洲心血管影像协会2015年指南，获取所有超声参数以计算左心室质量指数。还记录了其他临床特征，包括年龄、性别、高血压病程、高血压治疗情况、生活方式、肾功能、空腹血糖和血脂谱。分别在30名和157名受试者中确定了MT和TT基因型。M235T基因型、高血压病程、体重指数和射血分数对左心室质量指数有统计学影响，在调整混杂因素后，TT携带者的左心室质量指数显著高于MT携带者。在越南原发性高血压患者中，M23T的TT基因型与更大的左心室质量相关。
