Maresh C M, Noble B J, Robertson K L, Harvey J S
Aviat Space Environ Med. 1985 Nov;56(11):1078-84.
Serum aldosterone, cortisol, and electrolyte concentration, and urinary aldosterone and electrolyte excretion responses were examined in seven low-altitude natives (LAN) (373 m or less, aged 19-25 yr) and nine moderate-altitude natives (MAN) (1,830-2,200 m, aged 19-23 yr) for 2 d at their own residence (home) altitude (PB 740 or 585 mm Hg, respectively) and later for 2 d during decompression at a simulated altitude of 4,270 m (PB 447 mm Hg). The LAN group demonstrated higher (p less than 0.05) serum cortisol concentrations and respiration rates, and lower (p less than 0.05) serum aldosterone and potassium, and urinary aldosterone, sodium, and potassium concentrations at certain times during decompression compared to their home responses. Moderate-altitude native responses, on the other hand, were generally unchanged. Manifestations of acute mountain sickness at PB 447 mm Hg were also significantly greater in the LAN group. Thus, it appears that the MAN subjects were influenced less by the drop in ambient oxygen tension associated with PB 447 mm Hg.
对7名低海拔本地人（LAN）（海拔373米及以下，年龄19 - 25岁）和9名中度海拔本地人（MAN）（海拔1830 - 2200米，年龄19 - 23岁）进行了研究，检测他们在各自居住海拔（分别为PB 740或585毫米汞柱）下2天的血清醛固酮、皮质醇和电解质浓度，以及尿醛固酮和电解质排泄反应，随后在模拟海拔4270米（PB 447毫米汞柱）减压过程中进行2天的检测。与在其居住海拔时的反应相比，LAN组在减压过程中的某些时段血清皮质醇浓度和呼吸频率更高（p < 0.05），而血清醛固酮、钾以及尿醛固酮、钠和钾浓度更低（p < 0.05）。另一方面，中度海拔本地人（MAN）的反应总体上没有变化。在PB 447毫米汞柱时，LAN组急性高山病的表现也明显更严重。因此，似乎MAN受试者受与PB 447毫米汞柱相关的环境氧分压下降的影响较小。
