Sutton J R, Viol G W, Gray G W, McFadden M, Keane P M
J Appl Physiol Respir Environ Exerc Physiol. 1977 Sep;43(3):421-4. doi: 10.1152/jappl.1977.43.3.421.
Responses of plasma renin activity, plasma aldosterone, plasma cortisol, and plasma electrolyte concentration and urinary electrolyte and aldosterone excretion were studied in four men during hypoxic decompression to a stimulated altitude of 4,760 m in a pressure chamber. Three of the four subjects developed significant acute mountain sickness. Plasma sodium and potassium concentrations were unchanged. No significant change in plasma renin activity was observed, but values tended to fall. Plasma aldosterone concentration was depressed while plasma cortisol was elevated and diurnal variation lost. Urinary sodium excretion was unchanged, but urinary potassium and aldosterone excretion were decreased. The decrease in plasma and urinary aldosterone and urinary potassium in the absence of change in plasma renin activity or plasma potassium is of uncertain origin. It is unlikely to be due to a decrease in adrenocorticotropin secretion since plasma cortisol rose during the same time. None of the changes could be causally implicated in the development of acute mountain sickness although the increase in plasma cortisol was greatest in the most ill.
在压力舱中，对四名男性进行低氧减压至模拟海拔4760米的过程中，研究了血浆肾素活性、血浆醛固酮、血浆皮质醇、血浆电解质浓度以及尿电解质和醛固酮排泄的反应。四名受试者中有三名出现了明显的急性高山病。血浆钠和钾浓度未发生变化。未观察到血浆肾素活性有显著变化，但数值有下降趋势。血浆醛固酮浓度降低，而血浆皮质醇升高且昼夜变化消失。尿钠排泄未改变，但尿钾和醛固酮排泄减少。在血浆肾素活性或血浆钾无变化的情况下，血浆和尿醛固酮以及尿钾的减少原因不明。不太可能是由于促肾上腺皮质激素分泌减少，因为在此期间血浆皮质醇升高。尽管病情最严重者血浆皮质醇升高幅度最大，但这些变化均与急性高山病的发生无因果关系。
