Algate D R, Beard D J
Arzneimittelforschung. 1985;35(10):1577-9.
The anticholinergic/antispasmodic agent oxybutynin does not induce physical dependence in rats when administered by oral gavage twice daily for 40 days; nor did challenge with naloxone precipitate withdrawal signs in these (oxybutynin-treated) animals. In contrast, morphine treatment resulted in a high degree of physical dependence as evidenced by the withdrawal signs noted after treatment was halted. Challenge with naloxone also induced severe withdrawal signs in morphine-treated rats. Withdrawal signs characterised by squealing, teeth chattering and "wet-dog" shakes were seen in one from five morphine-treated rats challenged with oxybutynin.
抗胆碱能/抗痉挛药物奥昔布宁每日经口灌胃给药两次，连续给药40天，不会使大鼠产生身体依赖性；用纳洛酮激发也不会使这些（接受奥昔布宁治疗的）动物出现戒断症状。相比之下，吗啡治疗导致高度身体依赖性，停药后出现的戒断症状证明了这一点。用纳洛酮激发也会在接受吗啡治疗的大鼠中诱发严重的戒断症状。在接受奥昔布宁激发的五分之一接受吗啡治疗的大鼠中，出现了以尖叫、打牙颤和“湿狗”样抖动为特征的戒断症状。
