Hamman Nicholas A, Dajel Titus B, Saiyejo Mohammed B, Abubakar Saidu B, Dansanda Bashir, Saeedu Hayatu, Tahir Kabiru, Hamza Muhammad, Iliyasu Garba, Chedi Basheer Z, Habib Abdulrazaq G
Snakebite Treatment & Research Hospital, Kaltungo, Gombe state, Nigeria.
Comprehensive Health Center Zamko, Langtang, Plateau state, Nigeria.
Toxicon. 2025 Nov;266:108510. doi: 10.1016/j.toxicon.2025.108510. Epub 2025 Jul 29.
The effectiveness and safety of antivenoms used for snakebite-envenoming can be evaluated in in-vitro, in-vivo preclinical and clinical studies. In this study, we evaluated the clinical effectiveness of a newly introduced Alternative Equine-derived Polyvalent (AEP) antivenom. Compared to the existing antivenoms, patients treated with the AEP antivenom showed higher mortality, more frequent early-adverse-reactions, and failure to restore clotting timely among carpet viper envenomed patients with coagulopathy. In contrast to existing antivenoms, the AEP failed to protect against deaths among patients with coagulopathy even after adjusting for potential confounders in a logistic regression model and restricting the analysis to patients who received optimal doses. None of the antivenoms protected against deaths among patients without coagulopathy.
用于治疗蛇咬伤中毒的抗蛇毒血清的有效性和安全性可在体外、临床前体内及临床研究中进行评估。在本研究中，我们评估了一种新引入的替代马源多价（AEP）抗蛇毒血清的临床有效性。与现有的抗蛇毒血清相比，在患有凝血病的地毯蝰蛇中毒患者中，接受AEP抗蛇毒血清治疗的患者死亡率更高、早期不良反应更频繁，且未能及时恢复凝血功能。与现有抗蛇毒血清不同，即使在逻辑回归模型中对潜在混杂因素进行调整并将分析限制在接受最佳剂量的患者中，AEP仍未能预防凝血病患者死亡。没有一种抗蛇毒血清能预防非凝血病患者死亡。
