Spence S J, Silverman J A, Corbett D
Behav Brain Res. 1985 Sep-Oct;17(2):117-24. doi: 10.1016/0166-4328(85)90024-5.
Intracranial self-stimulation (ICSS) was obtained from 3 areas of anteromedial cortex: the prelimbic area (Brodman's area 32), the anterior cingulate area and the posterior cingulate area. Electrical stimulation in the prelimbic and anterior cingulate areas also produces a behavioral inhibition which is most pronounced at anterior sites (i.e. prelimbic) and declines at increasingly more posterior sites. It was found that the acquisition of responding for ICSS and the magnitude of amphetamine's facilitation of ICSS were inversely related to the degree of behavioral inhibition. These data and the ability of amphetamine to reverse prefrontal stimulation-induced inhibition suggest an important interaction between the prefrontal cortex and the mesolimbic dopamine systems in the control of goal-directed behavior. A model involving cortical suppression of mesolimbic dopamine function is discussed.
颅内自我刺激（ICSS）可从前内侧皮质的3个区域获得：前边缘区（布罗德曼32区）、前扣带回区和后扣带回区。在前边缘区和前扣带回区进行电刺激也会产生行为抑制，这种抑制在前部区域（即前边缘区）最为明显，并在越来越靠后的部位逐渐减弱。研究发现，对ICSS反应的习得以及苯丙胺对ICSS促进作用的大小与行为抑制程度呈负相关。这些数据以及苯丙胺逆转前额叶刺激诱导的抑制的能力表明，前额叶皮质与中脑边缘多巴胺系统在控制目标导向行为方面存在重要相互作用。文中讨论了一个涉及皮质对中脑边缘多巴胺功能抑制的模型。
