Mogenson G J, Takigawa M, Robertson A, Wu M
Brain Res. 1979 Aug 3;171(2):247-59. doi: 10.1016/0006-8993(79)90331-7.
The contribution of dopaminergic neurons to self-stimulation of the ventral tegmental area, nucleus accumbens and prefrontal cortex was investigated. The ventral tegmental area is the site of non-striatal dopaminergic neurons and their axons project to the nucleus accumbens and prefrontal cortex. Injections of spiroperidol, a dopamine antagonist, into the nucleus accumbens significantly reduced self-stimulation of the ipsilateral ventral tegmental area but did not influence self-stimulation of the contralateral ventral tegmental area. Injections of spiroperidol into the prefrontal cortex did not reduce self-stimulation of the ipsilateral or contralateral ventral tegmental area. Electrical stimulation of sites in the nucleus accumbens positive for self-stimulation antidromically activated neurons of the ventral tegmental area, and a reduction of discharge of these neurons following administration of apomorphine suggested that they were dopaminergic neurons. These observations provide additional evidence implicating dopaminergic neurons in brain-stimulation reward and suggest that dopaminergic neurons contribute to self-stimulation of the nucleus accumbens but not the prefrontal cortex.
研究了多巴胺能神经元对腹侧被盖区、伏隔核和前额叶皮质自我刺激的作用。腹侧被盖区是非纹状体多巴胺能神经元的所在部位，其轴突投射到伏隔核和前额叶皮质。向伏隔核注射多巴胺拮抗剂螺哌啶可显著降低同侧腹侧被盖区的自我刺激，但不影响对侧腹侧被盖区的自我刺激。向前额叶皮质注射螺哌啶不会降低同侧或对侧腹侧被盖区的自我刺激。对伏隔核中自我刺激阳性位点的电刺激可逆向激活腹侧被盖区的神经元，而注射阿扑吗啡后这些神经元放电减少表明它们是多巴胺能神经元。这些观察结果提供了更多证据，表明多巴胺能神经元与脑刺激奖赏有关，并提示多巴胺能神经元对伏隔核的自我刺激有贡献，但对前额叶皮质的自我刺激没有贡献。
