Winschel Timothy R, Weinhold Kellie, Schnell Patrick M, Gorka Stephanie, Lustberg Maryam, Aase Darrin, Melink Zihan, Kopec Rachel, Picino Chase, Li Ziqi, Oppong Bridget, Williams Nicole, Orchard Tonya S
Human Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH, 43210, USA.
Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA.
Support Care Cancer. 2025 Jul 31;33(8):736. doi: 10.1007/s00520-025-09789-9.
Cancer related cognitive impairment is frequently reported by cancer survivors. The purpose of this study was to determine the association of the MIND diet pattern and its components with cognitive function in breast cancer survivors following chemotherapy.
This was a cross-sectional study of 30 post-menopausal breast cancer survivors within one year of completing chemotherapy; 21 had complete data for analysis. Cognitive outcomes were assessed using a battery of objective tests. Self-reported dietary data were collected through electronic food frequency questionnaire; nutritional biomarkers were measured in blood. Linear regression models assessed the associations between the MIND diet score and its components with cognitive outcomes.
Adherence to the MIND diet pattern was positively associated with global cognitive score (β = 1.163, p = 0.013), episodic memory (β = 3.726, p = 0.019), attention/working memory (β = 4.046, p = 0.024) and phonemic fluency (β = 42.305, p = 0.002) adjusting for education and total energy intake. Foods emphasized in the MIND diet such as non-fried fish, vegetables, and beans/legumes were all positively associated with cognitive performance on individual tests (p < 0.05 for all). Blood biomarkers of vegetable (β-carotene) and non-fried fish (docosahexaenoic acid (DHA)) correlated with self-reported intake. Blood DHA was correlated with better cognitive performance (p < 0.05) Additionally, moderate intake of red meat and lower intake of fast food were positively associated with cognitive performance (p < 0.05 for both).
Among post-menopausal breast cancer survivors that are within one year of completing chemotherapy, adherence to the MIND diet pattern and its components was associated with better cognitive function.
癌症幸存者经常报告与癌症相关的认知障碍。本研究的目的是确定MIND饮食模式及其组成部分与化疗后乳腺癌幸存者认知功能之间的关联。
这是一项对30名在完成化疗后一年内的绝经后乳腺癌幸存者进行的横断面研究；21名有完整数据用于分析。使用一系列客观测试评估认知结果。通过电子食物频率问卷收集自我报告的饮食数据；测量血液中的营养生物标志物。线性回归模型评估MIND饮食评分及其组成部分与认知结果之间的关联。
在调整教育程度和总能量摄入后，坚持MIND饮食模式与整体认知评分（β = 1.163，p = 0.013）、情景记忆（β = 3.726，p = 0.019）、注意力/工作记忆（β = 4.046，p = 0.024）和音素流畅性（β = 42.305，p = 0.002）呈正相关。MIND饮食中强调的食物，如非油炸鱼、蔬菜和豆类，在各项测试中均与认知表现呈正相关（所有p < 0.05）。蔬菜（β-胡萝卜素）和非油炸鱼（二十二碳六烯酸（DHA））的血液生物标志物与自我报告的摄入量相关。血液DHA与更好的认知表现相关（p < 0.05）。此外，适量摄入红肉和较少摄入快餐与认知表现呈正相关（两者p < 0.05）。
在完成化疗后一年内的绝经后乳腺癌幸存者中，坚持MIND饮食模式及其组成部分与更好的认知功能相关。
