Aboutalebi Hamideh, Vafaei Shayan, Aboutalebi Mohammad, Dortaj Hengameh, Alipour Fatemeh, Bideskan Alireza Ebrahimzadeh-
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Faculty of Medicine and Surgery, Tor Vergata University, Rome, Italy.
J Ovarian Res. 2025 Jul 31;18(1):171. doi: 10.1186/s13048-025-01677-4.
One of the important discussions in assisted reproductive technology (ART) is to maintain fertility in those who are at risk of losing their fertility for various reasons, including cancer and the use of anti-cancer therapies, hence finding a way to maintain fertility during chemotherapy, is vital. Nowadays, in addition to successfully treating patients, oncologists have also focused their attention on preserving their patients' potential of the latter to conceive. Chemotherapy-related ovarian failure, which manifests as a non-physiological form of amenorrhea, can cause dysfunction of the ovary. It is hypothesized that chemotherapeutic agents may cause DNA damage, accelerate follicular apoptosis, oxidative stress, resulting in loss of ovarian reserve function. Hence investigation on utilization of alternatives in order to maintain ovarian function and fertility in cancer survivors seems important. This review provides an update on available and potential future prospects for fertility preservation in women treated with chemotherapy.
辅助生殖技术（ART）中的一项重要讨论是如何维持那些因各种原因（包括癌症和使用抗癌疗法）而面临生育能力丧失风险的人的生育能力，因此找到在化疗期间维持生育能力的方法至关重要。如今，除了成功治疗患者外，肿瘤学家还将注意力集中在保留患者的受孕潜力上。化疗相关的卵巢功能衰竭表现为非生理性闭经，可导致卵巢功能障碍。据推测，化疗药物可能会导致DNA损伤、加速卵泡凋亡、氧化应激，从而导致卵巢储备功能丧失。因此，研究利用替代方法来维持癌症幸存者的卵巢功能和生育能力似乎很重要。这篇综述提供了关于接受化疗的女性生育力保存的现有方法和潜在未来前景的最新信息。
