干细胞衍生外泌体与干细胞疗法
Stem cell-derived exosome versus stem cell therapy.
作者信息
Zhang Kaiyue, Cheng Ke
机构信息
Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC USA.
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
出版信息
Nat Rev Bioeng. 2023 Apr 12:1-2. doi: 10.1038/s44222-023-00064-2.
Abstract
Stem cell therapies are being explored for the treatment of various diseases, including haematological disease, immune disease, neurodegenerative disease, and tissue injuries. Alternatively, stem cell-derived exosomes may provide similar clinical benefits without the biosafety concerns associated with the transplantation of living cells. However, large-scale manufacturing and purification, batch-to-batch variation, and analysis of the complex cargos of exosomes will need to be addressed to enable their clinical translation.
摘要
干细胞疗法正在被探索用于治疗各种疾病，包括血液疾病、免疫疾病、神经退行性疾病和组织损伤。或者，干细胞衍生的外泌体可能提供类似的临床益处，而没有与活细胞移植相关的生物安全问题。然而，为了使其能够进行临床转化，需要解决外泌体的大规模制造和纯化、批次间差异以及对其复杂货物的分析等问题。
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