Meffin P J, Sallustio B C, Purdie Y J, Robson R A, Wing L M, Brooks P M
Br J Clin Pharmacol. 1985 Oct;20(4):414-6. doi: 10.1111/j.1365-2125.1985.tb05087.x.
The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10-fold higher than endogenous levels. The clearance and steady-state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co-administration.
在8名男性受试者中研究了泼尼松龙的处置情况，这些受试者分为两组，一组同时给予皮质醇，使血浆皮质醇浓度比内源性水平高10倍，另一组不给予。总泼尼松龙的清除率和稳态分布容积增加，泼尼松龙游离分数也增加，但同时给予皮质醇对未结合泼尼松龙的清除率没有影响。
