Cortisol does not inhibit prednisolone clearance.
作者信息
Meffin P J, Sallustio B C, Purdie Y J, Robson R A, Wing L M, Brooks P M
出版信息
Br J Clin Pharmacol. 1985 Oct;20(4):414-6. doi: 10.1111/j.1365-2125.1985.tb05087.x.
Abstract
The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10-fold higher than endogenous levels. The clearance and steady-state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co-administration.
摘要
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