吲哚洛尔与普萘洛尔浓度-反应关系的对比。
Contrasts between pindolol and propranolol concentration-response relationships.
作者信息
Carruthers S G, Pacha W L, Aellig W H
出版信息
Br J Clin Pharmacol. 1985 Oct;20(4):417-20. doi: 10.1111/j.1365-2125.1985.tb05088.x.
Abstract
The plasma concentration-response relationships of oral and intravenous pindolol and propranolol have been studied in a group of eight healthy male subjects who received each dosage form in a randomized single-blind cross-over manner. Despite similar elimination half-lives, the duration of action of pindolol was longer than that of propranolol. This longer duration of action was associated with a flatter concentration-response curve for pindolol and may be related to the partial agonist activity of pindolol. Propranolol concentration-response curves were dependent on the route of drug administration whereas pindolol curves were similar following oral and intravenous routes of administration.
摘要
在一组8名健康男性受试者中，以随机单盲交叉方式给予口服和静脉注射的吲哚洛尔及普萘洛尔，研究了它们的血浆浓度-反应关系。尽管吲哚洛尔和普萘洛尔的消除半衰期相似，但吲哚洛尔的作用持续时间比普萘洛尔长。这种较长的作用持续时间与吲哚洛尔较平缓的浓度-反应曲线有关，可能与吲哚洛尔的部分激动剂活性有关。普萘洛尔的浓度-反应曲线取决于给药途径，而吲哚洛尔的曲线在口服和静脉给药后相似。
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