急性和慢性给药后吲哚洛尔与普萘洛尔对心率影响的比较。
Comparison of the effect of pindolol and propranolol on heart rate after acute and chronic administration.
作者信息
Finch M B, O'Connor P C, Harron D W, Shanks R G
出版信息
Br J Clin Pharmacol. 1983 Apr;15(4):431-4. doi: 10.1111/j.1365-2125.1983.tb01526.x.
Abstract
1 The present study compared the effects in healthy volunteers of the acute and chronic administration of placebo, pindolol and propranolol to see if the partial agonist activity of pindolol was reduced by the beta-adrenoceptor blocking activity of pindolol on chronic administration. 2 Five subjects received in random order for 8 days placebo, propranolol 160 mg and pindolol 10 mg; on days 1 and 8 treatments were given twice at 0 and 2 h. Heart rate in supine position and at end of exercise was recorded before dosing and at 2 and 4 h post-dosing on days 1 and 8. 3 Propranolol and pindolol reduced exercise heart rate to the same extent on days 1 and 8. 4 Propranolol reduced supine heart rate more than pindolol on days 1 and 8 but the difference was only significant on day 8.
摘要
- 本研究比较了安慰剂、吲哚洛尔和普萘洛尔急性及慢性给药对健康志愿者的影响，以观察吲哚洛尔的部分激动剂活性在慢性给药时是否会因吲哚洛尔的β-肾上腺素能受体阻断活性而降低。2. 五名受试者按随机顺序接受为期8天的安慰剂、160毫克普萘洛尔和10毫克吲哚洛尔治疗；在第1天和第8天，在0小时和2小时各给药两次。在第1天和第8天给药前以及给药后2小时和4小时记录仰卧位心率和运动结束时的心率。3. 在第1天和第8天，普萘洛尔和吲哚洛尔降低运动心率的程度相同。4. 在第1天和第8天，普萘洛尔降低仰卧位心率的幅度大于吲哚洛尔，但差异仅在第8天显著。
相似文献
1
Comparison of the effect of pindolol and propranolol on heart rate after acute and chronic administration.急性和慢性给药后吲哚洛尔与普萘洛尔对心率影响的比较。
Br J Clin Pharmacol. 1983 Apr;15(4):431-4. doi: 10.1111/j.1365-2125.1983.tb01526.x.
2
beta-Adrenoceptor blocking activity and duration of action of pindolol and propranolol in healthy volunteers.健康志愿者中吲哚洛尔和普萘洛尔的β-肾上腺素受体阻断活性及作用持续时间
Br J Clin Pharmacol. 1976 Apr;3(2):251-7. doi: 10.1111/j.1365-2125.1976.tb00600.x.
3
Comparison of the haemodynamic effects of bucindolol, propranolol and pindolol in healthy volunteers.布新洛尔、普萘洛尔和吲哚洛尔对健康志愿者血流动力学影响的比较。
Br J Clin Pharmacol. 1985 Dec;20(6):659-67. doi: 10.1111/j.1365-2125.1985.tb05125.x.
4
A comparison of the acute haemodynamic effects of propranolol and pindolol at rest and during supine exercise in man.普萘洛尔与吲哚洛尔在人体静息及仰卧位运动时的急性血流动力学效应比较。
Clin Sci (Lond). 1980 Dec;59 Suppl 6:465s-468s. doi: 10.1042/cs059465s.
5
Effects of propranolol and pindolol on plasma ANP levels in humans at rest and during exercise.普萘洛尔和吲哚洛尔对静息及运动状态下人体血浆心钠素水平的影响。
Am J Physiol. 1989 Aug;257(2 Pt 2):R259-64. doi: 10.1152/ajpregu.1989.257.2.R259.
6
Effect of beta blockade and intrinsic sympathomimetic activity on exercise performance.β受体阻滞剂及内在拟交感活性对运动能力的影响。
Am J Cardiol. 1984 Dec 1;54(10):1337-41. doi: 10.1016/s0002-9149(84)80093-4.
7
Effect of propranolol and pindolol on the up-regulation of lymphocytic beta adrenoceptors during acute submaximal physical exercise. A placebo-controlled double-blind study.普萘洛尔和吲哚洛尔对急性次最大量体育锻炼期间淋巴细胞β肾上腺素能受体上调的影响。一项安慰剂对照双盲研究。
J Cardiovasc Pharmacol. 1990 Apr;15(4):544-51. doi: 10.1097/00005344-199004000-00004.
8
An assessment of the partial agonist activity of Ro 31-1118, flusoxolol and pindolol in man.罗 31-1118、氟索洛尔和吲哚洛尔在人体中的部分激动剂活性评估。
Br J Clin Pharmacol. 1987 Nov;24(5):571-80. doi: 10.1111/j.1365-2125.1987.tb03215.x.
9
Clinical pharmacology of pindolol.吲哚洛尔的临床药理学
Am Heart J. 1982 Aug;104(2 Pt 2):346-56. doi: 10.1016/0002-8703(82)90125-9.
10
Exercise haemodynamic effects of beta-blockade and intrinsic sympathomimetic activity.β受体阻滞剂和内在拟交感活性的运动血流动力学效应。
Eur J Clin Pharmacol. 1989;36(1):5-10. doi: 10.1007/BF00561015.
引用本文的文献
1
"Sit back, observe, and wait." Or is there a pharmacologic preventive treatment for cerebral aneurysms?“坐观其变，静候佳音。”那么，针对脑动脉瘤是否存在药物预防治疗方法呢？
Neurosurg Rev. 2013 Jan;36(1):1-9; discussion 9-10. doi: 10.1007/s10143-012-0429-7. Epub 2012 Oct 16.
2
Effect on heart rate over 24 hours of pindolol administered for 14 days.服用14天的吲哚洛尔对24小时心率的影响。
Eur J Clin Pharmacol. 1984;27(5):535-8. doi: 10.1007/BF00556888.
3
Human pharmacokinetic and pharmacodynamic studies on Ro31-1118, a new beta-adrenoceptor antagonist.新型β-肾上腺素能受体拮抗剂Ro31-1118的人体药代动力学和药效学研究。
Br J Clin Pharmacol. 1985 Mar;19(3):319-27. doi: 10.1111/j.1365-2125.1985.tb02650.x.
4
Characterization of the beta-adrenoreceptors which mediate the isoprenaline-induced changes in finger tremor and cardiovascular function in man.介导异丙肾上腺素引起的人体手指震颤和心血管功能变化的β-肾上腺素能受体的特性研究。
Eur J Clin Pharmacol. 1988;35(5):507-14. doi: 10.1007/BF00558246.
本文引用的文献
1
A comparison of the acute haemodynamic effects of propranolol and pindolol at rest and during supine exercise in man.普萘洛尔与吲哚洛尔在人体静息及仰卧位运动时的急性血流动力学效应比较。
Clin Sci (Lond). 1980 Dec;59 Suppl 6:465s-468s. doi: 10.1042/cs059465s.
2
Measurement of partial agonist activity of pindolol.吲哚洛尔部分激动剂活性的测定。
Clin Pharmacol Ther. 1981 Nov;30(5):581-6. doi: 10.1038/clpt.1981.207.
3
A pharmacodynamic and pharmacokinetic comparison of pindolol 20 mg retard and a conventional tablet.20毫克缓释吲哚洛尔与普通片剂的药效学和药代动力学比较。
Eur J Clin Pharmacol. 1981;20(3):179-83. doi: 10.1007/BF00544595.
4
Adrenergic beta receptor blockade: hemodynamic importance of intrinsic sympathomimetic activity at rest.
Clin Pharmacol Ther. 1981 Jun;29(6):711-8. doi: 10.1038/clpt.1981.100.
5
The haemodynamic effects of ( )-propranolol, dexpropranolol, oxprenolol, practolol and sotalol in anaesthetised dogs.（）-普萘洛尔、右旋普萘洛尔、氧烯洛尔、普拉洛尔和索他洛尔对麻醉犬的血流动力学影响。
Eur J Pharmacol. 1972 Jan;17(1):123-34. doi: 10.1016/0014-2999(72)90278-6.
6
Comparative chronotropic activity of beta-adrenoceptive antagonists.β-肾上腺素能拮抗剂的比较变时活性
Br J Pharmacol. 1970 Nov;40(3):373-81. doi: 10.1111/j.1476-5381.1970.tb10619.x.
7
Letter: Paradoxical effect of pindolol.信件：吲哚洛尔的矛盾效应。
Br Med J. 1975 Jul 19;3(5976):155-6. doi: 10.1136/bmj.3.5976.155-a.
8
The effect of pindolol on exercise-induced cardiac acceleration in relation to plasma levels in man.吲哚洛尔对人体运动诱发的心脏加速与血浆水平关系的影响。
Clin Pharmacol Ther. 1975 Feb;17(2):127-33. doi: 10.1002/cpt1975172127.
9
beta-Adrenoceptor blocking activity and duration of action of pindolol and propranolol in healthy volunteers.健康志愿者中吲哚洛尔和普萘洛尔的β-肾上腺素受体阻断活性及作用持续时间
Br J Clin Pharmacol. 1976 Apr;3(2):251-7. doi: 10.1111/j.1365-2125.1976.tb00600.x.
10
Comparison of the duration of action of pindolol and slow release oxprenolol in healthy volunteers.健康志愿者中吲哚洛尔与缓释氧烯洛尔作用持续时间的比较。
Eur J Clin Pharmacol. 1978 Nov 27;14(3):167-9. doi: 10.1007/BF02089955.
Zotero 插件