慢性特发性荨麻疹对组胺的风团及潮红反应增强。
Enhanced weal and flare response to histamine in chronic idiopathic urticaria.
作者信息
Krause L B, Shuster S
出版信息
Br J Clin Pharmacol. 1985 Nov;20(5):486-8. doi: 10.1111/j.1365-2125.1985.tb05103.x.
Abstract
Weal and flare histamine dose-responses were measured in 30 normal subjects and 15 patients with chronic idiopathic urticaria. The log dose-response curves were shifted to the left corresponding to an increase in histamine potency of 2.5 for weal and 3.1 for flare. An enhanced response to histamine may be important in chronic idiopathic urticaria and comparison of potency of antihistamines in different subjects may be unreliable where initial weal response is abnormal.
摘要
在30名正常受试者和15名慢性特发性荨麻疹患者中测量了风团和红晕的组胺剂量反应。对数剂量反应曲线向左移动，对应于风团的组胺效力增加2.5倍，红晕增加3.1倍。对组胺的反应增强在慢性特发性荨麻疹中可能很重要，并且在初始风团反应异常的情况下，比较不同受试者中抗组胺药的效力可能不可靠。
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本文引用的文献
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