前列腺素D2对组胺诱导的人体皮肤风团的影响。
Effect of prostaglandin D2 on histamine-induced weals in human skin.
作者信息
Barnes V F, Heavey D J
出版信息
Br J Pharmacol. 1986 Feb;87(2):357-60. doi: 10.1111/j.1476-5381.1986.tb10824.x.
The effect of prostaglandin D2 (PGD2) on weal response to intradermal injection of histamine was examined in normal volunteers. Co-injection of variable amounts of PGD2 with a fixed dose of histamine (2.5 nmol) was made so that the molar ratio of histamine: PGD2 covered the range 15 to 1215. There was no significant effect of PGD2 on weal area. PGD2, present at a 50 times lower concentration than histamine, had no effect on either the dose-response curves for the histamine-induced weal area or the forearm weal volume response to 2.5 nmol histamine. It is concluded that PGD2, when present at the relative amounts found in vitro and in vivo, has no effect on the weal response to histamine in man.
在正常志愿者中研究了前列腺素D2（PGD2）对皮内注射组胺所致风团反应的影响。将不同量的PGD2与固定剂量的组胺（2.5 nmol）共同注射，以使组胺与PGD2的摩尔比范围为15至1215。PGD2对风团面积无显著影响。PGD2的浓度比组胺低50倍，对组胺诱导的风团面积剂量反应曲线或对2.5 nmol组胺的前臂风团体积反应均无影响。结论是，当PGD2以体外和体内发现的相对量存在时，对人对组胺的风团反应没有影响。
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