Dogra S C, Khanduja K L, Gupta M P
Br J Cancer. 1985 Dec;52(6):931-5. doi: 10.1038/bjc.1985.279.
The present investigation shows the effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung carcinogenesis in male Wistar rats. Lung tumours were induced by giving three intratracheal instillations, one week apart, of 10 mg benzo(a)pyrene per instillation. Maximum tumour incidence (100%) and tumour burden per rat was found in rats which were kept on vitamin A deficient diet for 4 weeks prior to the first administration and 8 weeks after the last administration of benzo(a)pyrene. Rats in which vitamin A deficiency was terminated after the last administration of the carcinogen had 83% tumour incidence, whereas corresponding control pairfed animals had 39% incidence of tumours. These data represent the values obtained 32 weeks after the last administered dose of the carcinogen and indicate the role of vitamin A, both in the initiation as well as in the postinitiation phases of lung carcinogenesis.
本研究显示了维生素A缺乏对雄性Wistar大鼠苯并(a)芘诱导的肺癌发生起始阶段和起始后阶段的影响。通过每隔一周进行三次气管内滴注，每次滴注10mg苯并(a)芘来诱导肺部肿瘤。在首次给药前4周和最后一次给药后8周保持维生素A缺乏饮食的大鼠中，发现了最高的肿瘤发生率（100%）和每只大鼠的肿瘤负荷。在最后一次给予致癌物后终止维生素A缺乏的大鼠，肿瘤发生率为83%，而相应的配对喂养对照动物的肿瘤发生率为39%。这些数据代表了最后一次给予致癌物剂量32周后获得的值，并表明了维生素A在肺癌发生起始阶段以及起始后阶段的作用。
