Stezzi Marc, Brose Marcia, Gordon Sarah W, Solomides Charalambos, Tuluc Madalina, Miller Jeffrey
Department of Endocrinology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
JCEM Case Rep. 2025 Jul 31;3(9):luaf172. doi: 10.1210/jcemcr/luaf172. eCollection 2025 Sep.
Typical carcinoid tumors, or low-grade neuroendocrine tumors (NETs), are a rare class of neoplasms that share histopathological characteristics with other NETs like medullary thyroid cancer (MTC). Here, we report an 85-year-old woman with a history of left hemithyroidectomy in the 1980s (pathology not available) and right-sided multinodular goiter biopsied as benign, initially misdiagnosed with metastatic MTC based on lung nodule biopsy staining for calcitonin. The lung nodule was surgically removed and shown to be a well-differentiated lung NET. This case demonstrates the diagnostic challenges of integrating cytopathological findings, such as calcitonin staining, with the overall clinical scenario to arrive at an accurate diagnosis.
典型类癌肿瘤，即低级别神经内分泌肿瘤（NETs），是一类罕见的肿瘤，与其他神经内分泌肿瘤如甲状腺髓样癌（MTC）具有共同的组织病理学特征。在此，我们报告一名85岁女性，她在20世纪80年代有左侧甲状腺叶切除术病史（病理情况不详），右侧多结节性甲状腺肿活检为良性，最初基于肺结节活检降钙素染色被误诊为转移性甲状腺髓样癌。肺结节经手术切除，结果显示为高分化肺神经内分泌肿瘤。该病例表明，将细胞病理学检查结果（如降钙素染色）与整体临床情况相结合以得出准确诊断存在诊断挑战。
