Poff Charles, Buckman Vincent, Jung David, Liao Chuanhong, Shi Lewis, Maassen Nicholas H
Department of Orthopaedic Surgery and Rehabilitation Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Department of Biostatistics, University of Chicago Medical Center, Chicago, IL, USA.
J Shoulder Elb Arthroplast. 2025 Jul 28;9:24715492251348793. doi: 10.1177/24715492251348793. eCollection 2025.
Tranexamic Acid (TXA) has been associated with improved range of motion (ROM) in knee arthroplasty literature. The primary aim of this study is to assess the association between perioperative TXA in Total Shoulder Arthroplasty (TSA) and ROM up to 12-months postoperatively. The authors hypothesized there would be no difference between groups.
A single-institution retrospective cohort study of patients who underwent TSA between 2012-2022 was performed. Shoulder ROM was recorded pre-operatively, 3-months, 6-months, and 9-12-months postoperatively. Secondary outcomes including blood loss, transfusions, pain scores, and 90-day complications were collected. Statistical analyses were performed using STATA/SE.
A total of 551 TSAs were included. Pre-operative elevation was greater in the TXA group (90.1° vs 74.0°, < .001). Elevation was significantly greater at 3, 6, and 9-12 months postoperatively in the TXA group (106.7°, 124.7°, 129.4°) compared to controls (95.0°, 109.3°, 117.1°) ( < .006). When propensity match analysis was performed to control for preoperative ROM, elevation was significantly greater at 6 months in the TXA group ( = .001).
Patients who received perioperative TXA had significantly improved elevation at 6-months following TSA compared to controls. The results suggest there may be a link between postoperative ROM and TXA in TSA. III.
在膝关节置换术的文献中，氨甲环酸（TXA）与改善活动范围（ROM）有关。本研究的主要目的是评估全肩关节置换术（TSA）围手术期使用TXA与术后12个月内ROM之间的关联。作者假设两组之间无差异。
对2012年至2022年间接受TSA的患者进行单机构回顾性队列研究。记录术前、术后3个月、6个月和9至12个月的肩关节ROM。收集包括失血量、输血情况、疼痛评分和90天并发症在内的次要结局指标。使用STATA/SE进行统计分析。
共纳入551例TSA患者。TXA组术前抬高角度更大（90.°对74.0°，P<0.001）。与对照组（95.0°、109.3°、117.1°）相比，TXA组术后3个月、6个月和9至12个月的抬高角度明显更大（106.7°、124.7°、129.4°）（P<0.006）。进行倾向匹配分析以控制术前ROM时，TXA组在6个月时的抬高角度明显更大（P=0.001）。
与对照组相比，接受围手术期TXA的患者在TSA术后6个月时抬高角度有显著改善。结果表明TSA术后ROM与TXA之间可能存在联系。III。
