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颈椎原发性尤因肉瘤:一例报告。

Primary Ewing's sarcoma of the cervical vertebra: A case report.

作者信息

Elaitari K, Jabour S, Boujida N, Allali N, Chat L, El Kababri M, Kili A, Hessissein L, Regragui A, El Haddad S

机构信息

Department of Radiology, Rabat Children's Hospital, University Mohammed V of Rabat, Morocco.

Department of Pediatric Hematology and Oncology, Rabat Children's Hospital, University Mohammed V of Rabat, Morocco.

出版信息

Radiol Case Rep. 2025 Jul 24;20(10):5116-5121. doi: 10.1016/j.radcr.2025.06.055. eCollection 2025 Oct.

DOI:10.1016/j.radcr.2025.06.055
PMID:40746745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12311511/
Abstract

Ewing's sarcoma is an aggressive small round cell tumor and represents the second most common malignant bone neoplasm in children, following osteosarcoma. However, spinal Ewing's sarcoma is a rare entity in children, with extra-vertebral locations being more common. This case is distinguished by several particularities: atypical initial symptoms, and a diagnostic delay possibly related to either underestimation by the family or false reassurance from an initially unremarkable standard radiograph; unusual vertebral involvement; and a cervical location, which is even more exceptional. Moreover, there is an overlap in radiological and histological presentations with other tumor types, highlighting the importance of multidisciplinary correlation (clinical, radiological, and histopathological) to establish an accurate diagnosis. The patient underwent surgical decompression followed by chemotherapy. Disease progression was subsequently observed on follow-up imaging.

摘要

尤因肉瘤是一种侵袭性小圆细胞肿瘤,是儿童第二常见的恶性骨肿瘤,仅次于骨肉瘤。然而,儿童脊柱尤因肉瘤是一种罕见的疾病,椎体外部位更为常见。该病例有几个特殊之处:非典型的初始症状,诊断延迟可能与家庭的低估或最初无异常的标准X线片给予的错误安慰有关;不寻常的椎体受累;以及颈椎部位,这更为罕见。此外,其影像学和组织学表现与其他肿瘤类型存在重叠,凸显了多学科关联(临床、影像学和组织病理学)对于准确诊断的重要性。患者接受了手术减压,随后进行化疗。后续影像学检查观察到疾病进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/12311511/88361545800d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/12311511/27abc0cc2d18/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/12311511/347083731552/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/12311511/88361545800d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/12311511/27abc0cc2d18/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/12311511/347083731552/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2676/12311511/88361545800d/gr3.jpg

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本文引用的文献

1
A rare case of Ewing's sarcoma primary of the cervical spine in a 1-year-old child: A case report and literature review.一名1岁儿童颈椎原发性尤因肉瘤罕见病例:病例报告及文献综述
Int J Surg Case Rep. 2024 Sep;122:110020. doi: 10.1016/j.ijscr.2024.110020. Epub 2024 Jul 14.
2
Novel Targeted Therapeutic Strategies for Ewing Sarcoma.尤因肉瘤的新型靶向治疗策略
Cancers (Basel). 2022 Apr 14;14(8):1988. doi: 10.3390/cancers14081988.
3
Skull and Spinal Ewing's Sarcoma in Children: An Institutional Study.儿童颅骨和脊柱尤因肉瘤:一项机构研究。
J Pediatr Neurosci. 2018 Oct-Dec;13(4):392-397. doi: 10.4103/JPN.JPN_109_18.
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NKX2.2 immunohistochemistry in the distinction of Ewing sarcoma from cytomorphologic mimics: Diagnostic utility and pitfalls.NKX2.2 免疫组化在鉴别尤因肉瘤与其细胞形态学模拟物中的作用:诊断效用及陷阱。
Cancer Cytopathol. 2018 Nov;126(11):942-949. doi: 10.1002/cncy.22056. Epub 2018 Oct 30.
5
Imaging features of Ewing's sarcoma: Special reference to uncommon features and rare sites of presentation.尤因肉瘤的影像学特征:特别提及不常见特征及罕见的发病部位。
J Cancer Res Ther. 2018 Jul-Sep;14(5):1014-1022. doi: 10.4103/jcrt.JCRT_1350_16.
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Primary Ewing's Sarcoma of the Spine in a Two-Year-Old Boy.一名两岁男童的原发性脊柱尤因肉瘤
Case Rep Orthop. 2016;2016:8027137. doi: 10.1155/2016/8027137. Epub 2016 Nov 8.
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[Ewing/PNET sarcoma family of tumors: towards a new paradigm?].[尤因肉瘤/原始神经外胚层肿瘤家族性肿瘤:迈向新范式?]
Ann Pathol. 2015 Jan;35(1):86-97. doi: 10.1016/j.annpat.2014.11.001. Epub 2014 Dec 18.
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Primary tumors of the spine.脊柱原发性肿瘤。
Semin Musculoskelet Radiol. 2014 Jul;18(3):280-99. doi: 10.1055/s-0034-1375570. Epub 2014 Jun 4.
9
Imaging findings of the spinal peripheral Ewing's sarcoma family of tumours.脊柱外周尤文氏肉瘤家族肿瘤的影像学表现。
Clin Radiol. 2014 Feb;69(2):179-85. doi: 10.1016/j.crad.2013.09.010. Epub 2013 Nov 2.
10
Primary Ewing sarcoma of the spine mimicking a psoas abscess secondary to spinal infection.脊柱原发性尤因肉瘤酷似继发于脊柱感染的腰大肌脓肿。
Spine (Phila Pa 1976). 2009 Apr 20;34(9):E337-41. doi: 10.1097/BRS.0b013e3181995ec2.