Bai Linyu, Shi Jia, Du Xiaogang
Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China.
Kidney Med. 2025 Jun 25;7(8):101055. doi: 10.1016/j.xkme.2025.101055. eCollection 2025 Aug.
Chronic kidney disease-associated pruritus (CKD-aP) is a common and burdensome dermatologic condition in which patients can experience various symptoms. This study aimed to summarize and describe the patient-reported outcomes (PROs) and patient-reported outcome measures (PROMs) used in CKD-aP studies over the past 5 years. A total of 99 studies were identified, which included 5 different PROs and 40 different PROMs. The most frequently evaluated PRO was pruritus (n = 99), followed by health-related quality of life (HRQoL) (n = 31), sleep disturbances (n = 12), psychiatric symptoms (n = 7), and other skin symptoms (n = 5). Among the 40 different PROMs, 19 were generic, 18 were skin-specific, and 3 were CKD-specific. The most commonly used PROMs in the PROs of pruritus, HRQoL, sleeping, and psychiatric symptoms were the visual analog scale (n = 47), dermatological life quality index (n = 8), Pittsburgh sleep quality index (n = 7), and Beck depression inventory (n = 3), respectively. The PROs and PROMs are common and effective tools for evaluating CKD-aP, but more high-quality studies and guidelines are needed to reach a clear consensus on their application.
慢性肾脏病相关性瘙痒（CKD-aP）是一种常见且负担沉重的皮肤病，患者会出现各种症状。本研究旨在总结和描述过去5年CKD-aP研究中使用的患者报告结局（PROs）和患者报告结局测量工具（PROMs）。共识别出99项研究，其中包括5种不同的PROs和40种不同的PROMs。评估最频繁的PRO是瘙痒（n = 99），其次是健康相关生活质量（HRQoL）（n = 31）、睡眠障碍（n = 12）、精神症状（n = 7）和其他皮肤症状（n = 5）。在40种不同的PROMs中，19种是通用型，18种是皮肤特异性，3种是CKD特异性。在瘙痒、HRQoL、睡眠和精神症状的PROs中，最常用的PROMs分别是视觉模拟量表（n = 47）、皮肤病生活质量指数（n = 8）、匹兹堡睡眠质量指数（n = 7）和贝克抑郁量表（n = 3）。PROs和PROMs是评估CKD-aP的常用且有效的工具，但需要更多高质量的研究和指南，以便就其应用达成明确共识。
