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Drug Test Anal. 2025 Sep;17(9):1662-1674. doi: 10.1002/dta.3869. Epub 2025 Feb 20.
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Unraveling the liver metabolomic profile of ADB-BUTINACA-induced hepatotoxicity.解析ADB-BUTINACA诱导的肝毒性的肝脏代谢组学特征。
Ecotoxicol Environ Saf. 2024 Dec;288:117375. doi: 10.1016/j.ecoenv.2024.117375. Epub 2024 Nov 26.
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Identification and characterization of etomidate and metomidate metabolites in zebrafish, HLMs and S9 fraction by quadrupole-orbitrap LC-MS/MS for drug control.采用四极杆-轨道阱液相色谱-串联质谱法鉴定和表征斑马鱼、人肝微粒体和S9组分中依托咪酯和甲咪酯的代谢产物用于药物控制。
J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Jan 1;1250:124374. doi: 10.1016/j.jchromb.2024.124374. Epub 2024 Nov 21.
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MDMB-4en-PINACA-Related Deaths in Cook County Jail: Awareness and Preventive Measures.库克县监狱中与MDMB-4en-PINACA相关的死亡事件:认识与预防措施
Am J Forensic Med Pathol. 2025 Mar 1;46(1):87-91. doi: 10.1097/PAF.0000000000000966. Epub 2024 Jun 28.
5
Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene.人对四种合成苯并咪唑类阿片类药物:异托米嗪、美托米嗪、依托米嗪和美托米嗪的代谢。
Arch Toxicol. 2024 Jul;98(7):2101-2116. doi: 10.1007/s00204-024-03735-0. Epub 2024 Apr 6.
6
Association between intoxication with psychoactive substances and adverse effects occurrence in consumers.精神活性物质中毒与消费者不良反应发生的关系。
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药物替代品——关于益处、风险、检测方法及管理策略的见解:一项系统综述

Drug substitutes - Insights on benefits, risks, detection methods, and management strategies: a systematic review.

作者信息

Bai Song, Li Miao, Tang Shouying, Wan Suran, Wu Rong, Chen Lijun, Wang Fang, Liu Shan

机构信息

Research Center for Green Chemistry and Ecological Environment Technology, Guizhou Industry Polytechnic College, Guiyang, China.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.

出版信息

Front Psychiatry. 2025 Jul 17;16:1600212. doi: 10.3389/fpsyt.2025.1600212. eCollection 2025.

DOI:10.3389/fpsyt.2025.1600212
PMID:40747264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12310920/
Abstract

The abuse of new psychoactive substances and narcotic drugs as drug substitutes poses a serious threat to public health and safety. This study outlines the effective use and negative abuse of drug substitutes and outlines associated criminal behaviors to help readers understand the potential risks of such substances. By summarizing the technical bottlenecks in the analysis and detection of criminal cases, this study highlights their impact on case discrimination, which in turn can limit or even render policy implementation ineffective. Finally, based on database analysis and the current regulatory system, flexible control strategies were proposed to address the constantly emerging "new" substances, providing a reference for relevant control guidelines to be formulated.

摘要

新型精神活性物质和麻醉药品作为毒品替代品的滥用对公众健康和安全构成严重威胁。本研究概述了毒品替代品的有效使用和负面滥用情况,并概述了相关犯罪行为,以帮助读者了解此类物质的潜在风险。通过总结刑事案件分析和检测中的技术瓶颈,本研究突出了它们对案件甄别工作的影响,进而可能限制甚至使政策实施无效。最后,基于数据库分析和现行监管体系,提出了灵活的管控策略,以应对不断出现的“新”物质,为制定相关管控指南提供参考。