He Yufeng, Yang Xi, He Xinghui, Wang Guoshuang, Li Chuang, Yuan Ping, Li Chunhong
Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Front Endocrinol (Lausanne). 2025 Jul 17;16:1589695. doi: 10.3389/fendo.2025.1589695. eCollection 2025.
Diabetic cardiomyopathy (DCM), a complication of type 2 diabetes mellitus (T2DM), is closely associated with key genes in the insulin signaling pathway. Insulin regulates cellular metabolism and growth under normal conditions by activating downstream signaling pathways through its receptors. Nonetheless, insulin resistance, which compromises the insulin signaling pathway and impairs cardiovascular system performance, is common in individuals with T2DM. The key insulin signaling genes include IRS1, IRS2, PIK3R1, and GLUT4 play important roles in insulin receptor signaling, PI3K complex assembly, and glucose transport, respectively. Mutations or abnormal expression of these genes may lead to disorders in the insulin signaling pathway, affecting the normal regulation of glucose metabolism and impairment of myocardial function, thereby promoting the development of DCM. This review delves into the specific roles of these genes in the pathogenic mechanisms and treatment of DCM, with the aim of providing scientific evidence and guidance for future research endeavors.
糖尿病性心肌病（DCM）是2型糖尿病（T2DM）的一种并发症，与胰岛素信号通路中的关键基因密切相关。在正常情况下，胰岛素通过其受体激活下游信号通路来调节细胞代谢和生长。然而，胰岛素抵抗在T2DM患者中很常见，它会损害胰岛素信号通路并影响心血管系统功能。关键的胰岛素信号基因包括IRS1、IRS2、PIK3R1和GLUT4，它们分别在胰岛素受体信号传导、PI3K复合物组装和葡萄糖转运中发挥重要作用。这些基因的突变或异常表达可能导致胰岛素信号通路紊乱，影响葡萄糖代谢的正常调节并损害心肌功能，从而促进DCM的发展。本综述深入探讨了这些基因在DCM发病机制和治疗中的具体作用，旨在为未来的研究工作提供科学依据和指导。
