Yamamoto Shinkuro, Fukata Satoshi, Karashima Takashi, Kurabayashi Atsushi, Yoshimura Rie, Furihata Kaoru, Shiba Yuhei, Nao Tomoya, Satake Hirofumi, Inoue Keiji
Department of Urology, Kochi Medical School, Nankoku, 783-8505, Japan.
Department of Urology, Kochi Prefectural Aki General Hospital, Aki, 784-0027, Japan.
Urol Case Rep. 2025 Jul 23;62:103140. doi: 10.1016/j.eucr.2025.103140. eCollection 2025 Sep.
Renal cell carcinoma (RCC) with rhabdoid features is a rare and highly aggressive condition with no established treatment for early recurrence. We herein report a case involving a 58-year-old man who underwent nephrectomy for clear-cell RCC with rhabdoid features and developed rapid metastases within 3 months. Treatment with pembrolizumab plus lenvatinib achieved a sustained partial response, except for vertebral metastasis. Thereafter, radiotherapy was added, and systemic therapy resumed, which maintained disease control for 2 years. Immunohistochemistry revealed partial PD-L1 expression in rhabdoid areas. This case highlights the potential efficacy of pembrolizumab plus lenvatinib in RCC with rhabdoid features.
具有横纹肌样特征的肾细胞癌（RCC）是一种罕见且侵袭性很强的疾病，目前尚无针对早期复发的既定治疗方法。我们在此报告一例病例，患者为一名58岁男性，因具有横纹肌样特征的透明细胞RCC接受了肾切除术，并在3个月内出现快速转移。帕博利珠单抗联合乐伐替尼治疗取得了持续的部分缓解，但椎体转移除外。此后，加用了放射治疗，并恢复了全身治疗，疾病得到控制达2年。免疫组织化学显示横纹肌样区域有部分PD-L1表达。该病例突出了帕博利珠单抗联合乐伐替尼治疗具有横纹肌样特征的RCC的潜在疗效。
