最多等待 10 秒，若超时请稍后重试。
College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China.
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China.
Int J Mol Med. 2025 Oct;56(4). doi: 10.3892/ijmm.2025.5599. Epub 2025 Aug 1.
Cardiovascular disease (CVD) is a major global health threat, as its incidence and mortality rates continue to rise, highlighting the urgent need for effective therapeutic strategies. Histone deacetylase 4 (HDAC4), a member of class IIa HDACs, has attracted increasing attention in recent years for its role in CVD. Studies have shown that HDAC4 can influence the development and progression of CVD such as cardiac hypertrophy, hypertension and atherosclerosis by regulating key pathophysiological processes including inflammation, fibrosis and apoptosis. The present review focuses on the functional roles of HDAC4 in CVD and examines the effects of pharmacological agents and physical exercise on its expression. Future research should further elucidate the molecular mechanisms underlying HDAC4's involvement in CVD to provide new theoretical foundations for clinical diagnosis and treatment.
心血管疾病（CVD）是全球主要的健康威胁，因其发病率和死亡率持续上升，凸显了对有效治疗策略的迫切需求。组蛋白去乙酰化酶4（HDAC4）是IIa类组蛋白去乙酰化酶成员，近年来因其在心血管疾病中的作用而受到越来越多的关注。研究表明，HDAC4可通过调节炎症、纤维化和细胞凋亡等关键病理生理过程，影响心脏肥大、高血压和动脉粥样硬化等心血管疾病的发生发展。本综述重点关注HDAC4在心血管疾病中的功能作用，并探讨药物和体育锻炼对其表达的影响。未来的研究应进一步阐明HDAC4参与心血管疾病的分子机制，为临床诊断和治疗提供新的理论基础。
