Chen Zeshan, Deng Xin, Lu Yuanhong, Lu Ling, Qin Yijue, Qu Haishun, Lan Shaohang
Department of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region People's Hospital, Nanning, Guangxi 530016, P.R. China.
School of Basic Medical Sciences, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530200, P.R. China.
Oncol Rep. 2025 Oct;54(4). doi: 10.3892/or.2025.8957. Epub 2025 Aug 1.
microRNA‑214‑3p (miRNA‑214‑3p) can be mapped to the human chromosome 1q24.3 and is ~22 nucleotides in length. It has been garnering considerable attention due to its aberrant expression profile in various different types of cancer and its apparent role in regulating tumor progression. In malignant tumors, miRNA‑214‑3p can serve as a tumor suppressor or oncogene. This can be mediated by mainly inhibiting the expression of target genes by binding to the 3'‑untranslated region of target mRNAs, thereby regulating multiple downstream cellular processes, such as cell proliferation, metastasis, invasion and apoptosis. However, the role of miRNA‑214‑3p in cancer remains unclear. Therefore, in the present review, the role of miRNA‑214‑3p in cancer was summarized, whilst analyzing its potential as a biomarker for cancer diagnosis, prognosis and response to treatment. In addition, the present review evaluates its effects on sensitivity to chemotherapy, targeted therapy and radiotherapy. The current proposed strategies for the systemic delivery of miRNA‑214‑3p in cancer were also discussed.
微小RNA-214-3p（miRNA-214-3p）可定位于人类染色体1q24.3，长度约为22个核苷酸。由于其在各种不同类型癌症中的异常表达谱及其在调节肿瘤进展中明显的作用，它一直备受关注。在恶性肿瘤中，miRNA-214-3p可以作为肿瘤抑制因子或癌基因。这主要是通过与靶mRNA的3'-非翻译区结合来抑制靶基因的表达，从而调节多个下游细胞过程，如细胞增殖、转移、侵袭和凋亡。然而，miRNA-214-3p在癌症中的作用仍不清楚。因此，在本综述中，总结了miRNA-214-3p在癌症中的作用，同时分析了其作为癌症诊断、预后和治疗反应生物标志物的潜力。此外，本综述评估了其对化疗、靶向治疗和放疗敏感性的影响。还讨论了目前提出的在癌症中全身递送miRNA-214-3p的策略。
