Petriĭ O P, Gomazkov O A, Vladimirova N I
Biull Eksp Biol Med. 1985 Dec;100(12):649-52.
Kinin-damaging activity (KDA) has been studied in 8 brain areas of normotensive rats and rats with spontaneous hypertension, aged 3 to 12 months. A significant depression in KDA was revealed in midbrain, striatum, thalamus, and pituitary body of normotensive rats 6 months of age, as compared to 3-month-old animals. A tendency towards KDA increase was noted in the hypothalamus. In 12-month-old normotensive rats KDA level returned to baseline (3 months of age). Comparison of KDA in rats with spontaneous hypertension aged 3 to 12 months has revealed no age-dependent differences and it is, therefore, believed that rats with spontaneous hypertension lack certain mechanisms inducing a considerable decrease of KDA in 6-month-old normotensive rats.
在3至12月龄的正常血压大鼠和自发性高血压大鼠的8个脑区研究了激肽破坏活性（KDA）。与3月龄动物相比，6月龄正常血压大鼠的中脑、纹状体、丘脑和垂体中KDA显著降低。下丘脑中KDA有增加的趋势。12月龄正常血压大鼠的KDA水平恢复到基线（3月龄）。对3至12月龄自发性高血压大鼠的KDA进行比较，未发现年龄依赖性差异，因此认为自发性高血压大鼠缺乏某些机制，这些机制会导致6月龄正常血压大鼠的KDA显著降低。
