Spielmann M, Kac J, Elias D, Caille P, Le Chevalier T, Rougier P, Zummer K, Lasser P, Rouesse J
Bull Cancer. 1985;72(3):220-6.
We have treated 64 patients with esophageal squamous cell carcinoma using a combination of Vindesine 1.4 mg/m2 on day 1-2, Cyclophosphamide 200 mg/m2 on day 2-3-4, Cis-Platin 100 mg/m2 on day 3 and CCNU. 28 of the 37 patients considered to be inoperable were evaluable. We observed three complete responses and three partial responses in this group (overall response rate 21,5%). Twenty seven patients considered to be operable received the same chemotherapy without CCNU, owing to the risk of thrombopenia. 23 of these patients were evaluable in whom we observed 35% partial responses and no complete responses. No severe toxicity related to the chemotherapy protocol was observed. The mediocre results among the group of inoperable patients suggest that other chemotherapy protocols need to be tested. On the other hand, in the group of operable patients, the preliminary results encourage us to continue this study.
我们使用以下联合化疗方案治疗了64例食管鳞状细胞癌患者：第1 - 2天给予长春地辛1.4mg/m²，第2 - 3 - 4天给予环磷酰胺200mg/m²，第3天给予顺铂100mg/m²及洛莫司汀。37例被认为无法手术的患者中有28例可进行评估。我们在该组中观察到3例完全缓解和3例部分缓解（总缓解率为21.5%）。27例被认为可手术的患者由于有血小板减少的风险，未使用洛莫司汀而接受了相同的化疗方案。其中23例患者可进行评估，我们在这些患者中观察到35%的部分缓解，无完全缓解。未观察到与化疗方案相关的严重毒性。无法手术患者组的疗效一般，提示需要测试其他化疗方案。另一方面，在可手术患者组中，初步结果鼓励我们继续这项研究。
