Saint-André J P, Rousselet M C, Six P, Bertrand G, Soret J Y
Bull Cancer. 1985;72(5):414-22.
This paper recalls the definition of the Gleason index and describes the five architectural types that enable a calculation of the index. The conditions of the practical application of the index are defined, with a discussion of reproducibility of results based on current literature and the author's experience. The index allows appreciation of the developmental potential of prostatic cancer and distinguishes between patients with a high risk of metastases and death from the cancer and those with low potential development. While the Gleason index cannot predict the course of the tumour in any given patient, it can be considered a useful element among the clinical and biological factors assessed in the prognosis of prostatic carcinoma.
本文回顾了 Gleason 指数的定义,并描述了用于计算该指数的五种组织结构类型。定义了该指数实际应用的条件,并根据当前文献和作者经验讨论了结果的可重复性。该指数有助于评估前列腺癌的发展潜力,并区分发生转移和因癌症死亡风险高的患者与发展潜力低的患者。虽然 Gleason 指数无法预测任何特定患者肿瘤的病程,但它可被视为前列腺癌预后评估中临床和生物学因素中的一个有用因素。