Di Pietro Gianluca, Mennini Gianluca, Ciuffreda Antonella, Birtolo Lucia Ilaria, Cimino Sara, Celli Paola, Ascione Andrea, Iannello Licia, Galea Nicola, Maestrini Viviana
Department of Clinical, Internal, Anesthesiological and Cardiovascular Science, Sapienza University of Rome, Rome, Italy.
Department of General and Specialistic Surgery, Sapienza University of Rome, Rome, Italy.
JACC Case Rep. 2025 Jul 30;30(21):104336. doi: 10.1016/j.jaccas.2025.104336.
Whereas calcineurin inhibitors are usually the first choice for immunosuppression, cases of tacrolimus-induced reversible heart failure have been rarely described. To add to the existing limited literature and to help clinicians, we report 2 cases of patients who developed a dilated hypokinetic cardiomyopathy early after initiating this form of immunosuppression.
虽然钙调神经磷酸酶抑制剂通常是免疫抑制的首选药物，但他克莫司诱发可逆性心力衰竭的病例鲜有报道。为补充现有有限的文献资料并帮助临床医生，我们报告2例患者，他们在开始这种免疫抑制治疗后不久就出现了扩张型运动功能减退性心肌病。
