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经导管主动脉瓣置换术(TAVR)期间用于预防冠状动脉阻塞的球囊辅助瓣叶撕裂术:分步改良UNICORN法

Balloon-Assisted Leaflet Laceration to Prevent Coronary Obstruction During TAVR: Step-by-Step Modified UNICORN.

作者信息

Giustino Gennaro, Kipperman Robert, Koulogiannis Kostantinos, Brown John, Genereux Philippe

机构信息

Gagnon Cardiovascular Institute, Atlantic Health System, Morristown, New Jersey, USA.

Gagnon Cardiovascular Institute, Atlantic Health System, Morristown, New Jersey, USA.

出版信息

JACC Case Rep. 2025 Jul 30;30(21):104431. doi: 10.1016/j.jaccas.2025.104431.

Abstract

OBJECTIVES

Coronary obstruction (CO) is a life-threatening complication of transcatheter aortic valve replacement (TAVR). Undermining iatrogenic coronary obstruction with radiofrequency needle (UNICORN) has been recently described as a novel strategy to prevent CO during TAVR. We describe here the step-by-step technique of a modified version of UNICORN.

KEY STEPS

First, the target leaflet is traversed using transcatheter electrosurgery with a 0.014-inch wire. After successful leaflet traversal, the leaflet is first ballooned with a noncompliant coronary balloon. Then, the wire is exchanged with a stiff 0.035-inch wire. Over a 0.035-inch wire, the leaflet is completely lacerated with a large noncompliant balloon, and finally the transcatheter heart valve is implanted.

POTENTIAL PITFALLS

Electrosurgical traversal of the target aortic valve leaflet should be performed meticulously in the intended location and in front of the coronary ostium. After leaflet laceration, severe aortic regurgitation may result in hemodynamic instability. Cerebral embolic protection should always be used during leaflet modification.

CONCLUSIONS

Modified UNICORN is a viable alternative strategy to prevent CO during high-risk TAVR. Further data are needed to define its efficacy and safety.

摘要

目的

冠状动脉阻塞(CO)是经导管主动脉瓣置换术(TAVR)的一种危及生命的并发症。最近,用射频针破坏医源性冠状动脉阻塞(UNICORN)被描述为一种在TAVR期间预防CO的新策略。我们在此描述UNICORN改良版的分步技术。

关键步骤

首先,使用0.014英寸的导丝通过经导管电外科手术穿过目标瓣叶。成功穿过瓣叶后,先用非顺应性冠状动脉球囊对瓣叶进行扩张。然后,将导丝换成一根硬的0.035英寸导丝。通过一根0.035英寸的导丝,用一个大的非顺应性球囊将瓣叶完全撕裂,最后植入经导管心脏瓣膜。

潜在陷阱

目标主动脉瓣叶的电外科穿过应在预定位置且在冠状动脉口前方仔细进行。瓣叶撕裂后,严重的主动脉瓣反流可能导致血流动力学不稳定。在瓣叶改造过程中应始终使用脑栓塞保护装置。

结论

改良后的UNICORN是高危TAVR期间预防CO的一种可行替代策略。需要更多数据来确定其疗效和安全性。

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