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DNA-repair-driven cell death compels us to rethink cancer therapies.

作者信息

Szmyd Radoslaw, Gee Harriet E, Cesare Anthony J

机构信息

Genome Integrity Unit, Children's Medical Research Institute, University of Sydney, Sydney, New South Wales, Australia.

Radiation Oncology Network, Western Sydney Local Health District, Sydney, New South Wales, Australia.

出版信息

Nat Rev Mol Cell Biol. 2025 Aug 1. doi: 10.1038/s41580-025-00879-4.

DOI:10.1038/s41580-025-00879-4
PMID:40751092
Abstract
摘要

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本文引用的文献

[1]
SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis.

Mol Cell. 2025-3-6

[2]
Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage.

Nat Cell Biol. 2025-1

[3]
DNA damage induces p53-independent apoptosis through ribosome stalling.

Science. 2024-5-17

[4]
A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.

Nat Genet. 2024-4

[5]
POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling.

J Clin Invest. 2023-6-1

[6]
Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells.

Proc Natl Acad Sci U S A. 2021-11-30

[7]
Mutations in and differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy.

Nat Cancer. 2021-12

[8]
The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.

Nat Rev Mol Cell Biol. 2020-2-24

[9]
BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.

Nat Commun. 2019-7-17

[10]
DNA double-strand break repair-pathway choice in somatic mammalian cells.

Nat Rev Mol Cell Biol. 2019-7-1

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