Zhang Ao, Zhao Tianyi, Li Hongyi, Xia Tianyu, Zhang Shijie, Zhu Yuxin, Ding Kang
Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210001, China.
College of Landscape Architecture, Nanjing Forestry University, Nanjing, 210037, China.
BMC Public Health. 2025 Aug 1;25(1):2602. doi: 10.1186/s12889-025-23629-9.
Greenspace has been reported potential therapeutically beneficial for intestinal diseases, yet the findings remain controversial Current researches demonstrate diversity in the assessment of greenspace and involve broad population groups, with the publication bias remaining a concern. This study offers convincing and reliable evidence supporting the beneficial effects of greenspace exposure on intestinal health, through a systematic review and meta-analysis examining the association between greenspace and intestinal disorders. The Greenspace exposure was primarily assessed using the Normalized Difference Vegetation Index (NDVI) and residential proximity to greenspaces. A comprehensive assessment was conducted concurrently by integrating various methods, such as land-use and satellite image data. This research encompassed a variety of intestinal conditions, such as inflammatory bowel disease (IBD), Crohn's disease (CD), ulcerative colitis (UC), colorectal cancer (CRC), and diarrhea. A search was performed cross four English and two Chinese databases, yielding nine studies for systematic review and eight for meta-analysis from 11,497 identified records. The results illustrated a significant protective effect of greenspaces against CD and IBD as well as a potentially protective effect against diarrhea. Nonetheless, no significant association was detected for UC or CRC. The study established that greenspaces could influence intestinal health through potential mechanisms such as improved air quality, enhanced microbial diversity, and reduced stress. These findings provide a solid basis for developing healthier urban environments and advancing strategies for prevention and treatment of intestinal diseases.Trial registration Registration number: CRD42024625968.
据报道，绿地对肠道疾病具有潜在的治疗益处，但研究结果仍存在争议。目前的研究表明，在绿地评估方面存在多样性，涉及广泛的人群，发表偏倚仍是一个问题。本研究通过系统评价和荟萃分析，考察绿地与肠道疾病之间的关联，为绿地暴露对肠道健康的有益影响提供了令人信服且可靠的证据。绿地暴露主要通过归一化植被指数（NDVI）和住宅与绿地的距离来评估。同时，通过整合土地利用和卫星图像数据等多种方法进行了全面评估。本研究涵盖了多种肠道疾病，如炎症性肠病（IBD）、克罗恩病（CD）、溃疡性结肠炎（UC）、结直肠癌（CRC）和腹泻。在四个英文数据库和两个中文数据库中进行了检索，从11497条已识别记录中筛选出9项研究进行系统评价，8项研究进行荟萃分析。结果表明，绿地对CD和IBD具有显著的保护作用，对腹泻也具有潜在的保护作用。然而，未发现绿地与UC或CRC之间存在显著关联。该研究表明，绿地可能通过改善空气质量、增强微生物多样性和减轻压力等潜在机制影响肠道健康。这些发现为打造更健康的城市环境以及推进肠道疾病的预防和治疗策略提供了坚实的基础。试验注册 注册号：CRD42024625968。
