Chowdhury Paromita, Roy Anupam, Ghosh Santanu
Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, India.
Department of Pharmacy, Usha Martin University, Ranchi, 835103, India.
Small. 2025 Aug 2:e06450. doi: 10.1002/smll.202506450.
Reactive oxygen species (ROS) (superoxide anion (O ), singlet oxygen (O), hydroxyl radical (OH), and hydrogen peroxide (HO)) play a critical role in regulating diverse biological processes, e.g., inflammation, cell proliferation, and cell death. On the other hand, the generation of excess ROS can lead to oxidative stress, which is detrimental to biological systems and is implicated in ageing and numerous diseases. Various nanomaterials with unique and promising ROS-regulating properties have been explored in recent years. Transition metal dichalcogenides (TMDs) are a subclass of 2D nanomaterials that have attracted much interest lately. Among different TMDs, molybdenum disulfide (MoS) has been recognized as a promising nano-biomaterial due to its ROS-modulating properties along with biocompatible characteristics. This review summarizes recent advancements in the use of MoS for ROS-related biomedical applications, with a focus on the fundamental redox chemistry governing its ability to both generate and deplete ROS. Key factors influencing the redox behavior of MoS nanomaterials are discussed in detail. Additionally, the review highlights current findings on the biocompatibility and biodistribution of MoS-based systems. Finally, it concludes by highlighting emerging opportunities and future directions in this rapidly expanding field.
活性氧（ROS）（超氧阴离子（O ）、单线态氧（O）、羟基自由基（OH）和过氧化氢（HO））在调节多种生物过程中起着关键作用，例如炎症、细胞增殖和细胞死亡。另一方面，过量ROS的产生会导致氧化应激，这对生物系统有害，并与衰老和多种疾病有关。近年来，人们探索了各种具有独特且有前景的ROS调节特性的纳米材料。过渡金属二硫属化物（TMDs）是一类二维纳米材料，最近引起了人们的广泛关注。在不同的TMDs中，二硫化钼（MoS）因其ROS调节特性以及生物相容性而被认为是一种有前景的纳米生物材料。本文综述了MoS在ROS相关生物医学应用方面的最新进展，重点关注其产生和消耗ROS能力的基本氧化还原化学。详细讨论了影响MoS纳米材料氧化还原行为的关键因素。此外，综述还强调了基于MoS的系统在生物相容性和生物分布方面的当前研究结果。最后，通过强调这个快速发展领域中出现的机会和未来方向来结束本文。
